Journal article
Risk factors for suicide in bipolar I disorder in two prospectively studied cohorts
Journal of affective disorders, Vol.190, pp.1-5
01/15/2016
DOI: 10.1016/j.jad.2015.10.007
PMID: 26476155
Abstract
These analyses were undertaken to determine whether similar risk factors for suicide emerged across two prospectively studied cohorts of individuals with bipolar I disorder.
The NIMH Collaborative Study of Depression (CDS) recruited 288 patients with bipolar I disorder from 1978–1981 as they sought treatment. Subjects were followed semiannually and then annually for up to 30 years. The Bipolar Genomics studies identified individuals through clinical referrals and advertisement. Clinical follow-up did not occur but personal identifiers of 1748 were matched with National Death Index (NDI) records. Kaplan–Meier survival analyses tested ten potential risk factors.
The CDS and Genomic follow-ups encompassed 12,667 and 4529 person-years, respectively. Suicides/100 person-years were 0.26 and 0.055. The demographic or clinical variables that predicted suicide differed considerably in the two cohorts. The odds ratio for suicide for those with any history of suicide attempt was 2.3 and 2.8, respectively, and was the third highest odds ratio of the tested risk factors in both studies.
1.In one of the two cohorts, matching to the NDI was the only means available to ascertain death and cause of death.2.In one of the two cohorts, depressive symptom ratings were, in most cases, applied to those of a past major depressive episode.
Differences in the sources of participants in studies of suicide risk may result in marked differences across studies in both rates of suicide and in risk factors. A history of suicide attempt is a relatively robust risk factor across samples.
•Risk factors for suicide and bipolar I disorder can vary markedly depending on the sources of subjects and the methods of follow-up.•The most consistently observed risk factor for suicide in bipolar I disorder is a history of suicide attempt.•In neither study was a suicide attempt with high lethality or intent a stronger predictor of suicide than a history of any attempt.
Details
- Title: Subtitle
- Risk factors for suicide in bipolar I disorder in two prospectively studied cohorts
- Creators
- William Coryell - University of Iowa Carver College of Medicine, Department of Psychiatry, United StatesAbby Kriener - University of Iowa Carver College of Medicine, Department of Psychiatry, United StatesBrandon Butcher - University of Iowa Carver College of Medicine, Department of Psychiatry, United StatesJohn Nurnberger - Indiana University, Department of Psychiatry, United StatesFrancis McMahon - Johns Hopkins University, Department of Psychiatry, United StatesWade Berrettini - University of Pennsylvania, Department of Psychiatry, United StatesJess Fiedorowicz - University of Iowa Carver College of Medicine, Department of Psychiatry, United States
- Resource Type
- Journal article
- Publication Details
- Journal of affective disorders, Vol.190, pp.1-5
- DOI
- 10.1016/j.jad.2015.10.007
- PMID
- 26476155
- NLM abbreviation
- J Affect Disord
- ISSN
- 0165-0327
- eISSN
- 1573-2517
- Publisher
- Elsevier B.V
- Grant note
- DOI: 10.13039/100000025, name: NIMH, award: R01MH025416-33, R01MH059548-09; DOI: 10.13039/100001455, name: American Foundation for Suicide Prevention, award: #0006-2008B
- Language
- English
- Date published
- 01/15/2016
- Academic Unit
- Psychiatry; Epidemiology; Internal Medicine
- Record Identifier
- 9984003469302771
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