Risk for Asymptomatic Household Transmission of Clostridioides difficile Infection Associated with Recently Hospitalized Family Members

Aaron C Miller; Alan T Arakkal; Daniel K Sewell; Alberto M Segre; Sriram V Pemmaraju; Philip M Polgreen; CDC MInD-Healthcare Group

doi:10.3201/eid2805.212023

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Risk for Asymptomatic Household Transmission of Clostridioides difficile Infection Associated with Recently Hospitalized Family Members

Journal article

Open access

Peer reviewed

Risk for Asymptomatic Household Transmission of Clostridioides difficile Infection Associated with Recently Hospitalized Family Members

Aaron C Miller, Alan T Arakkal, Daniel K Sewell, Alberto M Segre, Sriram V Pemmaraju, Philip M Polgreen and CDC MInD-Healthcare Group

Emerging infectious diseases, Vol.28(5), pp.932-939

05/2022

DOI: 10.3201/eid2805.212023

PMCID: PMC9045444

PMID: 35447064

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Abstract

We evaluated whether hospitalized patients without diagnosed Clostridioides difficile infection (CDI) increased the risk for CDI among their family members after discharge. We used 2001-2017 US insurance claims data to compare monthly CDI incidence between persons in households with and without a family member hospitalized in the previous 60 days. CDI incidence among insurance enrollees exposed to a recently hospitalized family member was 73% greater than enrollees not exposed, and incidence increased with length of hospitalization among family members. We identified a dose-response relationship between total days of within-household hospitalization and CDI incidence rate ratio. Compared with persons whose family members were hospitalized <1 day, the incidence rate ratio increased from 1.30 (95% CI 1.19-1.41) for 1-3 days of hospitalization to 2.45 (95% CI 1.66-3.60) for >30 days of hospitalization. Asymptomatic C. difficile carriers discharged from hospitals could be a major source of community-associated CDI cases.

Clostridioides difficile

Clostridium Infections - epidemiology

Cross Infection - epidemiology

Family

Hospitalization

Humans

Risk Factors

Details

Title: Subtitle: Risk for Asymptomatic Household Transmission of Clostridioides difficile Infection Associated with Recently Hospitalized Family Members
Creators: Aaron C Miller
Alan T Arakkal
Daniel K Sewell
Alberto M Segre
Sriram V Pemmaraju
Philip M Polgreen
CDC MInD-Healthcare Group
Resource Type: Journal article
Publication Details: Emerging infectious diseases, Vol.28(5), pp.932-939
DOI: 10.3201/eid2805.212023
PMID: 35447064
PMCID: PMC9045444
NLM abbreviation: Emerg Infect Dis
ISSN: 1080-6040
eISSN: 1080-6059
Language: English
Date published: 05/2022
Academic Unit: Infectious Diseases; Epidemiology; Biostatistics; Nursing; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Computer Science; Public Policy Center (Archive); Internal Medicine
Record Identifier: 9984259470602771

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