Journal article
Risk management recommendations and patient acceptance vary with high-risk breast lesions
The American journal of surgery, Vol.223(1), pp.94-100
2021
DOI: 10.1016/j.amjsurg.2021.07.020
Abstract
Lobular carcinoma in situ (LCIS), atypical ductal and lobular hyperplasia (AH) increase breast cancer risk. We examined risk management recommendations (RMR) and acceptance in AH/LCIS.
All patients with AH/LCIS on core needle biopsy from 2013 to 2016 at our institution were identified; cancer patients were excluded. Univariate and multivariate analysis examined factors associated with management.
98 % of patients were evaluated by breast surgeons and 53 % underwent risk model calculation (RC). 77 % had new RMR. RMR of MRI screening (MRI), genetic counselling (GC) and medical oncology (MO) referral were 41 %, 18 %, 77 %, respectively. MRI screening was more likely recommended in those with strong family history (p = 0.01), and high RC (p < 0.001). Uptake of at least one RMR did not occur in 84 % of patients. Use of RC correlated with MO acceptance (p = 0.049).
Diagnosis of atypia has the potential to change risk management for most, however only 16 % of patients accepted all RMR.
•77 % of patients had new risk management recommendations with diagnosis of AH/LCIS.•84 % of patients did not accept at least one risk reducing recommendation.•Using a risk model was associated with uptake of medical oncology referral.
Details
- Title: Subtitle
- Risk management recommendations and patient acceptance vary with high-risk breast lesions
- Creators
- Anna C Beck - University of Iowa Hospitals and ClinicsSophia L Fu - Good Samaritan Hospital Medical CenterJunlin Liao - University of Iowa Hospitals and ClinicsAmani Bashir - University of Iowa Hospitals and ClinicsSonia L Sugg - University of Iowa Hospitals and ClinicsLillian M Erdahl - University of Iowa Hospitals and ClinicsRonald J Weigel - University of Iowa Hospitals and ClinicsIngrid M Lizarraga - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- The American journal of surgery, Vol.223(1), pp.94-100
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.amjsurg.2021.07.020
- ISSN
- 0002-9610
- eISSN
- 1879-1883
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: T32CA148062
- Language
- English
- Date published
- 2021
- Academic Unit
- Anatomy and Cell Biology; Biochemistry and Molecular Biology; Molecular Physiology and Biophysics; Surgery; Pathology
- Record Identifier
- 9984185277402771
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