Risk of Acute Kidney Injury After Primary and Revision Total Hip Arthroplasty and Total Knee Arthroplasty Using a Multimodal Approach to Perioperative Pain Control Including Ketorolac and Celecoxib

Lucian C Warth; Nicolas O Noiseux; Matthew H Hogue; Alison L Klaassen; Steve S Liu; John J Callaghan

doi:10.1016/j.arth.2015.08.012

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Risk of Acute Kidney Injury After Primary and Revision Total Hip Arthroplasty and Total Knee Arthroplasty Using a Multimodal Approach to Perioperative Pain Control Including Ketorolac and Celecoxib

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Risk of Acute Kidney Injury After Primary and Revision Total Hip Arthroplasty and Total Knee Arthroplasty Using a Multimodal Approach to Perioperative Pain Control Including Ketorolac and Celecoxib

Lucian C Warth, Nicolas O Noiseux, Matthew H Hogue, Alison L Klaassen, Steve S Liu and John J Callaghan

The Journal of arthroplasty, Vol.31(1), pp.253-255

01/2016

DOI: 10.1016/j.arth.2015.08.012

PMID: 26377377

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Abstract

Safe and effective perioperative analgesia is instrumental to patient satisfaction and decreasing LOS after TJA. We evaluated rates of acute kidney injury (AKI) in primary and revision TJA using a multimodal pain control regimen including scheduled celecoxib and PRN ketorolac. Postoperative AKI was identified in 43/903 (4.8%) of 903 of patients with adequate preoperative renal function. Those who developed AKI had significantly increased LOS (P < .01), were older, more obese, and more likely to have diabetes (P < .05). With a protocol incorporating NSAIDs in patients without evidence of preoperative renal impairment, there is a 4.8% rate of AKI, which is 2.7 times higher than the reported literature. Acute postoperative kidney injury was significantly correlated with increased LOS and has important patient safety and healthcare–related cost implications.

nonsteroidal anti-inflammatories

total hip arthroplasty

total knee arthroplasty

acute kidney injury

pain control

Details

Title: Subtitle: Risk of Acute Kidney Injury After Primary and Revision Total Hip Arthroplasty and Total Knee Arthroplasty Using a Multimodal Approach to Perioperative Pain Control Including Ketorolac and Celecoxib
Creators: Lucian C Warth - Hospital for Special Surgery, New York, New York
Nicolas O Noiseux - University of Iowa, Iowa City, Iowa
Matthew H Hogue - University of Iowa, Iowa City, Iowa
Alison L Klaassen - University of Iowa, Iowa City, Iowa
Steve S Liu - University of Iowa, Iowa City, Iowa
John J Callaghan - University of Iowa, Iowa City, Iowa
Resource Type: Journal article
Publication Details: The Journal of arthroplasty, Vol.31(1), pp.253-255
Publisher: Elsevier Inc
DOI: 10.1016/j.arth.2015.08.012
PMID: 26377377
ISSN: 0883-5403
eISSN: 1532-8406
Language: English
Date published: 01/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation
Record Identifier: 9984040265602771

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