Journal article
Risk of Breast Cancer in Families with Cleft Lip and Palate
Annals of epidemiology, Vol.22(1), pp.37-42
2012
DOI: 10.1016/j.annepidem.2011.09.003
PMCID: PMC3237814
PMID: 22037380
Abstract
To test whether female subjects in families with cleft lip and/or palate (CL/P) have an increased risk of breast cancer.
By using the Danish Facial Cleft Registry, we identified female subjects with CL/P, mothers of children with CL/P, and sisters to CL/P cases for the Danish birth cohorts 1911–1975. These subjects were compared with a 5% random sample of these cohorts regarding the incidence and age of onset for breast cancer registered in the Danish Hospital Discharge Register 1977–2005.
Examining 48,404 person-years for 1809 female CL/P cases (49 breast cancer cases) and 212,795 person-years for 7935 female relatives (188 breast cancer cases), we found no increased breast cancer risk for either CL/P cases (hazard ratio [HR], 1.23; 95% confidence interval (CI), 0.92–1.63), mothers of children with CL/P (HR, 0.93; 95% CI, 0.80–1.08), or sisters of CL/P cases (HR, 0.94; 95% CI, 0.55–1.60), nor was there any significant differences in age of onset.
Both epidemiological and genetic studies have suggested common etiological factors for breast cancer and CL/P. However, in this population-based study we were not able to confirm a general increase in the risk of breast cancer among female subjects in families with CL/P.
Details
- Title: Subtitle
- Risk of Breast Cancer in Families with Cleft Lip and Palate
- Creators
- Alexander Dietz - Children’s Hospital, University of Iowa, Iowa City, IADorthe Almind Pedersen - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, DenmarkRune Jacobsen - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, DenmarkGeorge L Wehby - Department of Health Management and Policy, College of Public Health, University of Iowa, Iowa City, IAJeffrey C Murray - Children’s Hospital, University of Iowa, Iowa City, IAKaare Christensen - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
- Resource Type
- Journal article
- Publication Details
- Annals of epidemiology, Vol.22(1), pp.37-42
- DOI
- 10.1016/j.annepidem.2011.09.003
- PMID
- 22037380
- PMCID
- PMC3237814
- NLM abbreviation
- Ann Epidemiol
- ISSN
- 1047-2797
- eISSN
- 1873-2585
- Publisher
- Elsevier Inc
- Grant note
- R01 DE11948, R01 DE08559, and R01 DE0020895 / NIH/NIDCR University of Iowa Medical Student Research Fellowship 1R01DD000295 / Center for Disease Control and Prevention (CDC)
- Language
- English
- Date published
- 2012
- Academic Unit
- Preventive and Community Dentistry; Anatomy and Cell Biology; Health Management and Policy; Stead Family Department of Pediatrics; Epidemiology; Economics; Pediatric Dentistry; Craniofacial Anomalies Research Center; Public Policy Center (Archive); Dental Research
- Record Identifier
- 9984025410702771
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