Risk of Cognitive Decline Associated With Paroxetine Use in Elderly Nursing Home Patients With Depression

Vishal Bali; Satabdi Chatterjee; Michael L Johnson; Hua Chen; Ryan M Carnahan; Rajender R Aparasu

doi:10.1177/1533317516673463

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Risk of Cognitive Decline Associated With Paroxetine Use in Elderly Nursing Home Patients With Depression

Journal article

Peer reviewed

Risk of Cognitive Decline Associated With Paroxetine Use in Elderly Nursing Home Patients With Depression

Vishal Bali, Satabdi Chatterjee, Michael L Johnson, Hua Chen, Ryan M Carnahan and Rajender R Aparasu

American journal of Alzheimer's disease and other dementias, Vol.31(8), pp.678-686

12/2016

DOI: 10.1177/1533317516673463

PMID: 27765867

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10852634/pdf/10.1177_1533317516673463.pdfView

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Abstract

This study evaluated the risk of cognitive decline associated with paroxetine use in elderly nursing home patients with depression. A retrospective cohort study was conducted using the 2007 to 2010 Medicare Part D claims and minimum data set (MDS) data involving new users of paroxetine and other selective serotonin reuptake inhibitors (SSRIs). The primary outcome was MDS Cognition Scale. The repeated-measures mixed model was used to examine the effect of paroxetine on cognition after controlling for other factors. The baseline MDS Cognition Scale measures for paroxetine (n = 63) and other SSRI users (n =1018) were 2.02 (±1.85) and 2.50 (±2.39), respectively. The repeated-measures mixed model did not find statistically significant difference in cognition with the use of paroxetine (β = 0.02, 95% CI: -0.16 to 0.21]) when compared to other SSRIs. There was no differential effect of paroxetine on cognition when compared to other SSRIs.

Depression - drug therapy

Nursing Homes

Humans

Serotonin Uptake Inhibitors - adverse effects

Female

Male

Risk

Aged

Homes for the Aged

Cognitive Dysfunction - chemically induced

Paroxetine - adverse effects

Details

Title: Subtitle: Risk of Cognitive Decline Associated With Paroxetine Use in Elderly Nursing Home Patients With Depression
Creators: Vishal Bali - Department of Pharmaceutical Health Outcomes and Policy, Texas Medical Center, College of Pharmacy, University of Houston, Houston, TX, USA
Satabdi Chatterjee - Department of Pharmaceutical Health Outcomes and Policy, Texas Medical Center, College of Pharmacy, University of Houston, Houston, TX, USA
Michael L Johnson - Department of Pharmaceutical Health Outcomes and Policy, Texas Medical Center, College of Pharmacy, University of Houston, Houston, TX, USA
Hua Chen - Department of Pharmaceutical Health Outcomes and Policy, Texas Medical Center, College of Pharmacy, University of Houston, Houston, TX, USA
Ryan M Carnahan - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA
Rajender R Aparasu - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA rraparasu@uh.edu
Resource Type: Journal article
Publication Details: American journal of Alzheimer's disease and other dementias, Vol.31(8), pp.678-686
DOI: 10.1177/1533317516673463
PMID: 27765867
NLM abbreviation: Am J Alzheimers Dis Other Demen
ISSN: 1533-3175
eISSN: 1938-2731
Publisher: United States
Grant note: R01 HS021264 / AHRQ HHS
Language: English
Date published: 12/2016
Academic Unit: Epidemiology; Injury Prevention Research Center
Record Identifier: 9983995027702771

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