Journal article
Risk of Development of Vulvar Cancer in Women With Lichen Sclerosus or Lichen Planus: A Systematic Review
Journal of lower genital tract disease, Vol.26(3), pp.250-257
07/01/2022
DOI: 10.1097/LGT.0000000000000673
PMID: 35285455
Abstract
OBJECTIVEVulvar lichen sclerosus (VLS) and possibly vulvar lichen planus (VLP) are associated with an increased vulvar cancer (VC) risk. We analyzed the risk of VC and its precursors after a diagnosis of VLS or VLP. MATERIALS AND METHODSA search was performed to identify articles describing the development of vulvar neoplasia in women with VLS or VLP. This systematic review was registered with the PROSPERO database. RESULTSFourteen studies on VLS included 14,030 women without a history of vulvar neoplasia. Vulvar cancer, differentiated vulvar intraepithelial neoplasia (dVIN), and vulvar high-grade squamous intraepithelial lesion occurred in 2.2% (314/14,030), 1.2% (50/4,175), and 0.4% (2/460), respectively. Considering women with previous or current VC, the rate was 4.0% (580/14,372). In one study, dVIN preceded VC in 52.0% of the cases. Progression of dVIN to VC was 18.1% (2/11).The risk was significantly higher in the first 1-3 years after a biopsy of VLS and with advancing age; it significantly decreased with ultrapotent topical steroid use.For the 14,268 women with VLP (8 studies), the rates of VC, dVIN, and vulvar high-grade squamous intraepithelial lesion were 0.3% (38/14,268), 2.5% (17/689), and 1.4% (10/711), respectively. CONCLUSIONSVulvar lichen sclerosus is associated with an increased risk of VC, especially in the presence of dVIN and with advancing age. Ultrapotent topical steroids seem to reduce this risk. An increased risk of developing VC has been suggested for VLP. Hence, treatment and regular life-long follow-up should be offered to women with VLS or VLP.
Details
- Title: Subtitle
- Risk of Development of Vulvar Cancer in Women With Lichen Sclerosus or Lichen Planus: A Systematic Review
- Creators
- Pedro Vieira-BaptistaFaustino R Pérez-LópezMaría T López-BaenaColleen K StockdaleMario PretiJacob Bornstein
- Resource Type
- Journal article
- Publication Details
- Journal of lower genital tract disease, Vol.26(3), pp.250-257
- DOI
- 10.1097/LGT.0000000000000673
- PMID
- 35285455
- ISSN
- 1526-0976
- eISSN
- 1526-0976
- Language
- English
- Date published
- 07/01/2022
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984318221502771
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