Journal article
Risk of Fracture in Women with Sarcopenia, Low Bone Mass, or Both
Journal of the American Geriatrics Society (JAGS), Vol.65(12), pp.2673-2678
12/01/2017
DOI: 10.1111/jgs.15050
PMCID: PMC5729083
PMID: 28960230
Abstract
OBJECTIVES: To determine whether women with sarcopenia and low bone mineral density (BMD) are at greater risk of clinical fractures than those with sarcopenia or low BMD alone.
DESIGN: Women's Health Initiative (WHI) Observational and Clinical trials.
SETTING: Three U.S. clinical centers (Pittsburgh, PA; Birmingham, AL; Phoenix/Tucson, AZ).
PARTICIPANTS: Women (mean age 63.3 +/- 0.07) with BMD measurements (N = 10,937).
MEASUREMENTS: Sarcopenia was defined as appendicular lean mass values corrected for height and fat mass. Low BMD was defined as a femoral neck T-score less than -1.0 based on the Third National Health and Nutrition Examination Survey reference database for white women. Cox proportional hazards analysis was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). We followed women for incident fractures over a median of 15.9 years.
RESULTS: Participants were classified into mutually exclusive groups based on BMD and sarcopenia status: normal BMD and no sarcopenia (n = 3,857, 35%), sarcopenia alone (n = 774, 7%), low BMD alone (n = 4,907, 45%), and low BMD and sarcopenia (n = 1,399, 13%). Women with low BMD, with (HR = 1.72, 95% CI = 1.44-2.06) or without sarcopenia (HR = 1.58, 95% CI = 1.37-1.83), had greater risk of fracture than women with normal BMD; the difference remained statistically significant after adjustment for important covariates. Women with low BMD, with (HR = 2.78, 95% CI = 1.78-4.30 and without (HR = 2.42, 95% CI = 1.63-3.59) sarcopenia had higher risk of hip fractures. Women with sarcopenia alone had similar HRs to women with normal BMD.
CONCLUSION: Compared to women with normal BMD.
Details
- Title: Subtitle
- Risk of Fracture in Women with Sarcopenia, Low Bone Mass, or Both
- Creators
- Rebekah Harris - University of PittsburghYuefang Chang - University of PittsburghKristen Beavers - Wake Forest UniversityDeepika Laddu-Patel - Stanford UniversityJennifer Bea - University of ArizonaKaren Johnson - University of Tennessee Health Science CenterMeryl LeBoff - Brigham and Women's HospitalCatherine Womack - Wake Forest UniversityRobert Wallace - University of IowaWenjun Li - University of Massachusetts Chan Medical SchoolCarolyn Crandall - University of California, Los AngelesJane Cauley - University of Pittsburgh
- Resource Type
- Journal article
- Publication Details
- Journal of the American Geriatrics Society (JAGS), Vol.65(12), pp.2673-2678
- DOI
- 10.1111/jgs.15050
- PMID
- 28960230
- PMCID
- PMC5729083
- NLM abbreviation
- J Am Geriatr Soc
- ISSN
- 0002-8614
- eISSN
- 1532-5415
- Publisher
- Wiley
- Number of pages
- 6
- Grant note
- HHSN268201100046C; HHSN268201100001C; HHSN268201100002C; HHSN268201100003C; HHSN268201100004C; HHSN271201100004C / National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) T32-AG-000181 / NIA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) T32AG000181 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Language
- English
- Date published
- 12/01/2017
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363607602771
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