Risk of Knee Osteoarthritis With Obesity, Sarcopenic Obesity, and Sarcopenia

Devyani Misra; Roger A Fielding; David T Felson; Jingbo Niu; Carrie Brown; Michael Nevitt; Cora E Lewis; James Torner; Tuhina Neogi; MOST study

doi:10.1002/art.40692

Journal article

Risk of Knee Osteoarthritis With Obesity, Sarcopenic Obesity, and Sarcopenia

Devyani Misra, Roger A Fielding, David T Felson, Jingbo Niu, Carrie Brown, Michael Nevitt, Cora E Lewis, James Torner, Tuhina Neogi and MOST study

Arthritis & rheumatology (Hoboken, N.J.), Vol.71(2), pp.232-237

02/2019

DOI: 10.1002/art.40692

PMCID: PMC6374038

PMID: 30106249

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https://www.ncbi.nlm.nih.gov/pmc/articles/6374038View

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Abstract

Obesity, defined by anthropometric measures, is a well-known risk factor for knee osteoarthritis (OA), but there is a relative paucity of data regarding the association of body composition (fat and muscle mass) with risk of knee OA. We undertook this study to examine the longitudinal association of body composition categories based on fat and muscle mass with risk of incident knee OA. We included participants from the Multicenter Osteoarthritis Study, a longitudinal cohort of individuals with or at risk of knee OA. Based on body composition (i.e., fat and muscle mass) from whole-body dual x-ray absorptiometry, subjects were categorized as obese nonsarcopenic (obese), sarcopenic obese, sarcopenic nonobese (sarcopenic), or nonsarcopenic nonobese (the referent category). We examined the relationship of baseline body composition categories with the risk of incident radiographic OA at 60 months using binomial regression with robust variance estimation, adjusting for potential confounders. Among 1,653 subjects without radiographic knee OA at baseline, significantly increased risk of incident radiographic knee OA was found among obese women (relative risk [RR] 2.29 [95% confidence interval {95% CI} 1.64-3.20]), obese men (RR 1.73 [95% CI 1.08-2.78]), and sarcopenic obese women (RR 2.09 [95% CI 1.17-3.73]), but not among sarcopenic obese men (RR 1.74 [95% CI 0.68-4.46]). Sarcopenia was not associated with risk of knee OA (for women, RR 0.96 [95% CI 0.62-1.49]; for men, RR 0.66 [95% CI 0.34-1.30]). In this large longitudinal cohort, we found body composition-based obesity and sarcopenic obesity, but not sarcopenia, to be associated with risk of knee OA. Weight loss strategies for knee OA should focus on obesity and sarcopenic obesity.

Body Composition

Humans

Middle Aged

Risk Factors

Sarcopenia - diagnostic imaging

Male

Adipose Tissue - diagnostic imaging

Osteoarthritis, Knee - epidemiology

Absorptiometry, Photon

Osteoarthritis, Knee - diagnostic imaging

Incidence

Sarcopenia - epidemiology

Muscle, Skeletal - diagnostic imaging

Obesity - epidemiology

Female

Aged

Longitudinal Studies

Obesity - diagnostic imaging

Details

Title: Subtitle: Risk of Knee Osteoarthritis With Obesity, Sarcopenic Obesity, and Sarcopenia
Creators: Devyani Misra - Boston University School of Medicine, Boston, Massachusetts
Roger A Fielding - Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts
David T Felson - Boston University School of Medicine, Boston, Massachusetts
Jingbo Niu - Boston University School of Medicine, Boston, Massachusetts
Carrie Brown - Boston University School of Medicine, Boston, Massachusetts
Michael Nevitt - University of California at San Francisco
Cora E Lewis - University of Alabama at Birmingham
James Torner - University of Iowa, Iowa City
Tuhina Neogi - Boston University School of Medicine, Boston, Massachusetts
MOST study
Resource Type: Journal article
Publication Details: Arthritis & rheumatology (Hoboken, N.J.), Vol.71(2), pp.232-237
DOI: 10.1002/art.40692
PMID: 30106249
PMCID: PMC6374038
NLM abbreviation: Arthritis Rheumatol
ISSN: 2326-5205
eISSN: 2326-5205
Publisher: United States
Grant note: U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS K24 AR070892 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS Rheumatology Research Foundation P60 AR047785 / NIAMS NIH HHS R01 AR062506 / NIAMS NIH HHS R01 AR071950 / NIAMS NIH HHS P30 DK056336 / NIDDK NIH HHS U01 AG018820 / NIA NIH HHS
Language: English
Date published: 02/2019
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995058002771

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