Risk of Oral Clefts in Twins

Dorthe GROSEN; Camilla BILLE; Inge PETERSEN; Axel SKYTTHE; Jacob VON BORNEMANN HJELMBORG; Jacob Krabbe Pedersen; Jeffrey Clark Murray; Kaare CHRISTENSEN

doi:10.1097/EDE.0b013e3182125f9c

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Risk of Oral Clefts in Twins

Dorthe GROSEN, Camilla BILLE, Inge PETERSEN, Axel SKYTTHE, Jacob VON BORNEMANN HJELMBORG, Jacob Krabbe Pedersen, Jeffrey Clark Murray and Kaare CHRISTENSEN

Epidemiology (Cambridge, Mass.), Vol.22(3), pp.313-319

2011

DOI: 10.1097/EDE.0b013e3182125f9c

PMCID: PMC3089024

PMID: 21423016

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Abstract

Background: Small studies have indicated that twinning increases the risk of oral cleft. Methods: We used data from a Danish national population-based cohort study to investigate whether twinning was associated with isolated oral cleft, and to estimate the twin probandwise concordance rate and heritability. Twins (207 affected/130,710) and singletons (7766 affected/4,798,526) born from 1936 through 2004 in Denmark were ascertained by linkage among the Danish Facial Cleft Database, the Danish Twin Registry, and the Civil Registration System. We computed oral cleft prevalence and prevalence proportion ratio for twins versus singletons, stratified for 3 subphenotypes. Probandwise concordance rates and heritability for twins were estimated for 2 phenotypes--cleft lip with or without cleft palate (CL/P) and cleft palate (CP). Results: The prevalence of oral cleft was 15.8 per 10,000 twins and 16.6 per 10,000 singletons (prevalence proportion ratio = 0.95; 95% confidence interval = 0.83-1.1). This prevalence was similar for monozygotic and dizygotic twins. The probandwise concordance rate was higher for CL/P for monozygotic twins than for dizygotic twins (50% vs. 8%, respectively). A similar contrast was present for CP. Recurrence risk for both types of clefts was greater in dizygotic twins than in non-twin siblings. Heritability estimates were above 90% for both CL/P and CP. Conclusions: No excess risk of oral cleft could be demonstrated for twins compared with singletons. The concordance rates and heritability estimates for both types of clefts show a strong genetic component.

Epidemiology

Public health. Hygiene-occupational medicine

Public health. Hygiene

General aspects

Miscellaneous

Otorhinolaryngology. Stomatology

Non tumoral diseases

Biological and medical sciences

Medical sciences

Facial bones, jaws, teeth, parodontium: diseases, semeiology

Details

Title: Subtitle: Risk of Oral Clefts in Twins
Creators: Dorthe GROSEN - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Camilla BILLE - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Inge PETERSEN - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Axel SKYTTHE - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Jacob VON BORNEMANN HJELMBORG - Department of Statistics, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Jacob Krabbe Pedersen - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Jeffrey Clark Murray - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Kaare CHRISTENSEN - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Resource Type: Journal article
Publication Details: Epidemiology (Cambridge, Mass.), Vol.22(3), pp.313-319
DOI: 10.1097/EDE.0b013e3182125f9c
PMID: 21423016
PMCID: PMC3089024
NLM abbreviation: Epidemiology
ISSN: 1044-3983
eISSN: 1531-5487
Publisher: Lippincott Williams & Wilkins; Philadelphia, PA
Language: English
Date published: 2011
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025414702771

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