Risk of Preeclampsia in Pregnancies After Assisted Reproductive Technology and Ovarian Stimulation

Angela S. Martin; Michael Monsour; Jennifer F. Kawwass; Sheree L. Boulet; Dmitry M. Kissin; Denise J. Jamieson

doi:10.1007/s10995-016-2067-0

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Risk of Preeclampsia in Pregnancies After Assisted Reproductive Technology and Ovarian Stimulation

Journal article

Peer reviewed

Risk of Preeclampsia in Pregnancies After Assisted Reproductive Technology and Ovarian Stimulation

Angela S. Martin, Michael Monsour, Jennifer F. Kawwass, Sheree L. Boulet, Dmitry M. Kissin and Denise J. Jamieson

Maternal and child health journal, Vol.20(10), pp.2050-2056

10/01/2016

DOI: 10.1007/s10995-016-2067-0

PMCID: PMC11057002

PMID: 27400915

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https://www.ncbi.nlm.nih.gov/pmc/articles/11057002View

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Abstract

Objective To compare the risk of preeclampsia among spontaneously conceived pregnancies to those after hyperestrogenic ovarian stimulation (hyperestrogenic OS) with and without assisted reproductive technology (ART), and stimulation with non-hyperestrogenic aromatase inhibitor stimulation (non-hyperestrogenic OS). Methods Live-born singleton deliveries among women 20-49 years were identified in the 2004-2012 Truven Health MarketScan Commercial Claims and Encounters Databases using ICD-9 and CPT codes. Maternal characteristics were compared using Chi squared and Fisher exact tests. We performed multilevel multivariable logistic regression, controlling for maternal age, parity, comorbid conditions, and region of delivery, and calculated adjusted odds ratios (aOR) and 95 % confidence intervals for mild and severe preeclampsia. Results 1,014,526 spontaneously conceived, 6881 hyperestrogenic OS with ART, 27,516 hyperestrogenic OS without ART, and 2117 non-hyperestrogenic OS pregnancies were identified. The adjusted odds of developing preeclampsia were increased for deliveries after hyperestrogenic OS with ART (mild preeclampsia aOR 1.42, 1.24-1.62; severe preeclampsia aOR 1.83, 1.59-2.11) and without ART (mild preeclampsia aOR 1.32, 1.24-1.42; severe preeclampsia aOR 1.53, 1.41-1.66). Adjusted odds of preeclampsia were similar between spontaneously conceived and non-hyperestrogenic OS pregnancies. Conclusions for Practice Risk of preeclampsia after ART may in part be related to supraphysiologic estrogen associated with hyperestrogenic OS.

Life Sciences & Biomedicine

Public, Environmental & Occupational Health

Science & Technology

Details

Title: Subtitle: Risk of Preeclampsia in Pregnancies After Assisted Reproductive Technology and Ovarian Stimulation
Creators: Angela S. Martin - Emory University
Michael Monsour - National Center for Chronic Disease Prevention and Health Promotion
Jennifer F. Kawwass - Emory University
Sheree L. Boulet - Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA
Dmitry M. Kissin - Emory University
Denise J. Jamieson - Emory University
Resource Type: Journal article
Publication Details: Maternal and child health journal, Vol.20(10), pp.2050-2056
DOI: 10.1007/s10995-016-2067-0
PMID: 27400915
PMCID: PMC11057002
NLM abbreviation: Matern Child Health J
ISSN: 1092-7875
eISSN: 1573-6628
Publisher: Springer Nature
Number of pages: 7
Language: English
Date published: 10/01/2016
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446514202771

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