Risk of Renal Cell Carcinoma Among Kidney Transplant Recipients in the United States

S Karami; E L Yanik; L E Moore; R M Pfeiffer; G Copeland; L Gonsalves; B Y Hernandez; C F Lynch; K Pawlish; E A Engels

doi:10.1111/ajt.13862

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Risk of Renal Cell Carcinoma Among Kidney Transplant Recipients in the United States

Journal article

Open access

Peer reviewed

Risk of Renal Cell Carcinoma Among Kidney Transplant Recipients in the United States

S Karami, E L Yanik, L E Moore, R M Pfeiffer, G Copeland, L Gonsalves, B Y Hernandez, C F Lynch, K Pawlish and E A Engels

American journal of transplantation, Vol.16(12), pp.3479-3489

12/2016

DOI: 10.1111/ajt.13862

PMCID: PMC5104677

PMID: 27160653

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Abstract

Renal cell carcinoma (RCC) is a common malignancy following kidney transplantation. We describe RCC risk and examine RCC risk factors among US kidney recipients (1987-2010). The Transplant Cancer Match Study links the US transplant registry with 15 cancer registries. Standardized incidence ratios (SIRs) were used to compare RCC risk (overall and for clear cell [ccRCC] and papillary subtypes) to the general population. Associations with risk factors were assessed using Cox models. We identified 683 RCCs among 116 208 kidney recipients. RCC risk was substantially elevated compared with the general population (SIR 5.68, 95% confidence interval 5.27-6.13), especially for papillary RCC (SIR 13.3 versus 3.98 for ccRCC). Among kidney recipients, RCC risk was significantly elevated for blacks compared to whites (hazard ratio [HR] 1.50) and lower in females than males (HR 0.56). RCC risk increased with prolonged dialysis preceding transplantation (p-trend < 0.0001). Risk was variably associated for RCC subtypes with some medical conditions that were indications for transplantation: ccRCC risk was reduced with polycystic kidney disease (HR 0.54), and papillary RCC was increased with hypertensive nephrosclerosis (HR 2.02) and vascular diseases (HR 1.86). In conclusion, kidney recipients experience substantially elevated risk of RCC, especially for papillary RCC, and multiple factors contribute to these cancers.

United States - epidemiology

Glomerular Filtration Rate

Kidney Failure, Chronic - surgery

Kidney Neoplasms - epidemiology

Prognosis

Follow-Up Studies

Humans

Middle Aged

Risk Factors

Graft Rejection - etiology

Male

Incidence

Kidney Function Tests

Carcinoma, Renal Cell - epidemiology

Graft Rejection - epidemiology

Kidney Neoplasms - etiology

Adult

Female

Carcinoma, Renal Cell - etiology

Postoperative Complications

Kidney Transplantation - adverse effects

Details

Title: Subtitle: Risk of Renal Cell Carcinoma Among Kidney Transplant Recipients in the United States
Creators: S Karami - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, MD
E L Yanik - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, MD
L E Moore - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, MD
R M Pfeiffer - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, MD
G Copeland - Michigan Cancer Surveillance Program, Michigan Department of Community Health, Lansing, MI
L Gonsalves - Connecticut Department of Public Health, Hartford, CT
B Y Hernandez - University of Hawaii Cancer Center, Honolulu, HI
C F Lynch - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA
K Pawlish - New Jersey State Cancer Registry, Cancer Epidemiology Services, New Jersey Department of Health, Trenton, NJ
E A Engels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, MD
Resource Type: Journal article
Publication Details: American journal of transplantation, Vol.16(12), pp.3479-3489
DOI: 10.1111/ajt.13862
PMID: 27160653
PMCID: PMC5104677
NLM abbreviation: Am J Transplant
ISSN: 1600-6143
eISSN: 1600-6143
Publisher: United States
Grant note: N01PC35142 / NCI NIH HHS HHSN261201000024C / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS U58 DP000824 / NCCDPHP CDC HHS HHSN261201000036C / NCI NIH HHS U58 DP003875 / NCCDPHP CDC HHS U58 DP003931 / NCCDPHP CDC HHS N01PC35137 / NCI NIH HHS U58 DP003921 / NCCDPHP CDC HHS U58 DP000832 / NCCDPHP CDC HHS HHSN261201000035C / NCI NIH HHS U58 DP003879 / NCCDPHP CDC HHS HHSN261201300011C / CCR NIH HHS HHSN261201300071C / NCI NIH HHS U58 DP003920 / NCCDPHP CDC HHS U58 DP000848 / NCCDPHP CDC HHS HHSN261201000034C / NCI NIH HHS N01PC35139 / NCI NIH HHS P30 CA086862 / NCI NIH HHS HHSN261201300021C / NCI NIH HHS HHSN261201300011I / NCI NIH HHS HHSN261201000037C / NCI NIH HHS N01PC35143 / NCI NIH HHS Z99 CA999999 / Intramural NIH HHS U58 DP003883 / NCCDPHP CDC HHS HHSN261201000035I / NCI NIH HHS
Language: English
Date published: 12/2016
Academic Unit: Epidemiology
Record Identifier: 9983995018902771

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