Journal article
Risk of Thyroid Cancer Among Solid Organ Transplant Recipients
American journal of transplantation, Vol.17(11), pp.2911-2921
11/2017
DOI: 10.1111/ajt.14310
PMCID: PMC5636643
PMID: 28397388
Abstract
Solid organ transplant recipients have an elevated incidence of thyroid cancer. We evaluated a wide range of potential risk factors in a cohort of 229 300 U.S. solid organ transplant recipients linked with 15 stage/regional cancer registries (1987-2012). Incidence rate ratios (IRRs) were adjusted for age, sex, race/ethnicity, transplanted organ, year of transplantation, and time since transplantation. Hazard ratios (HRs) for death and/or graft failure were adjusted for age, sex, race/ethnicity, transplanted organ, and year of transplantation. After transplantation, 356 thyroid cancers were diagnosed. Thyroid cancer incidence was 2.50-fold higher in transplant recipients than the general population (95% confidence interval [CI] 2.25-2.77). Among recipients of different organs, kidney recipients had the highest incidence of thyroid cancer (IRR = 1.26, 95% CI 1.03-1.53). Elevated thyroid cancer incidence was associated with cholestatic liver disease/cirrhosis as an indication for liver transplantation (IRR = 1.69, 95% CI 1.09-2.63), hypertensive nephrosclerosis as an indication for kidney transplantation (IRR = 1.41, 95% CI 1.03-1.94), and longer prior dialysis among kidney recipients (5+ vs. <1 year, IRR = 1.92, 95% CI 1.32-2.80; p-trend <0.01). Posttransplantation diagnosis of thyroid cancer was associated with modestly increased risk of death (HR = 1.33, 95% CI 1.02-1.73). Overall, our results suggest that end-stage organ disease and longer duration of dialysis may contribute to higher thyroid cancer incidence in transplant recipients.
Details
- Title: Subtitle
- Risk of Thyroid Cancer Among Solid Organ Transplant Recipients
- Creators
- C M Kitahara - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MDE L Yanik - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MDP W Ladenson - Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MDB Y Hernandez - University of Hawaii Cancer Center, University of Hawaii, Honolulu, HIC F Lynch - Department of Epidemiology, University of Iowa, Iowa City, IAK S Pawlish - Cancer Epidemiology Services, New Jersey Department of Health, Trenton, NJE A Engels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD
- Resource Type
- Journal article
- Publication Details
- American journal of transplantation, Vol.17(11), pp.2911-2921
- DOI
- 10.1111/ajt.14310
- PMID
- 28397388
- PMCID
- PMC5636643
- NLM abbreviation
- Am J Transplant
- ISSN
- 1600-6143
- eISSN
- 1600-6143
- Publisher
- United States
- Grant note
- N01PC35142 / NCI NIH HHS HHSN261201000024C / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS U58 DP000824 / NCCDPHP CDC HHS HHSN261201000036C / NCI NIH HHS U58 DP003875 / NCCDPHP CDC HHS U58 DP003931 / NCCDPHP CDC HHS N01PC35137 / NCI NIH HHS U58 DP003921 / NCCDPHP CDC HHS U58 DP000832 / NCCDPHP CDC HHS HHSN261201000035C / NCI NIH HHS U58 DP003879 / NCCDPHP CDC HHS HHSN261201300011C / CCR NIH HHS HHSN261201300071C / NCI NIH HHS P50 CA174521 / NCI NIH HHS U58 DP003920 / NCCDPHP CDC HHS U58 DP000848 / NCCDPHP CDC HHS HHSN261201000034C / NCI NIH HHS N01PC35139 / NCI NIH HHS P30 CA086862 / NCI NIH HHS HHSN261201300021C / NCI NIH HHS HHSN261201300011I / NCI NIH HHS HHSN261201000037C / NCI NIH HHS N01PC35143 / NCI NIH HHS Z99 CA999999 / Intramural NIH HHS U58 DP003883 / NCCDPHP CDC HHS HHSN261201000035I / NCI NIH HHS
- Language
- English
- Date published
- 11/2017
- Academic Unit
- Epidemiology
- Record Identifier
- 9983996067102771
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