Journal article
Risk of asynchronous contralateral breast cancer in noncarriers of BRCA1 and BRCA2 mutations with a family history of breast cancer: a report from the Women's Environmental Cancer and Radiation Epidemiology Study
Journal of clinical oncology, Vol.31(4), pp.433-439
02/01/2013
DOI: 10.1200/JCO.2012.43.2013
PMCID: PMC3731919
PMID: 23269995
Abstract
To fully characterize the risk of contralateral breast cancer (CBC) in patients with breast cancer with a family history who test negative for BRCA1 and BRCA2 mutations.
From our population-based case-control study comparing women with CBC to women with unilateral breast cancer (UBC), we selected women who tested negative for BRCA1 and BRCA2 mutations (594 patients with CBC/1,119 control patients with UBC). Rate ratios (RRs) and 95% CIs were estimated to examine the association between family history of breast cancer and risk of asynchronous CBC. Age- and family history-specific 10-year cumulative absolute risks of CBC were estimated.
Family history of breast cancer was associated with increased CBC risk; risk was highest among young women (< 45 years) with first-degree relatives affected at young ages (< 45 years; RR, 2.5; 95% CI, 1.1 to 5.3) or women with first-degree relatives with bilateral disease (RR, 3.6; 95% CI, 2.0 to 6.4). Women diagnosed with UBC before age 55 years with a first-degree family history of CBC had a 10-year risk of CBC of 15.6%.
Young women with breast cancer who have a family history of breast cancer and who test negative for deleterious mutations in BRCA1 and BRCA2 are at significantly greater risk of CBC than other breast cancer survivors. This risk varies with diagnosis age, family history of CBC, and degree of relationship to an affected relative. Women with a first-degree family history of bilateral disease have risks of CBC similar to mutation carriers. This has important implications for the clinical management of patients with breast cancer with family history of the disease.
Details
- Title: Subtitle
- Risk of asynchronous contralateral breast cancer in noncarriers of BRCA1 and BRCA2 mutations with a family history of breast cancer: a report from the Women's Environmental Cancer and Radiation Epidemiology Study
- Creators
- Anne S Reiner - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. reinera@mskcc.orgEsther M JohnJennifer D BrooksCharles F LynchLeslie BernsteinLene MellemkjærKathleen E MaloneJulia A KnightMarinela CapanuSharon N TeraokaPatrick ConcannonXiaolin LiangJane C FigueiredoSusan A SmithMarilyn StovallMalcolm C PikeRobert W HaileDuncan C ThomasColin B BeggJonine L Bernstein
- Resource Type
- Journal article
- Publication Details
- Journal of clinical oncology, Vol.31(4), pp.433-439
- Publisher
- United States
- DOI
- 10.1200/JCO.2012.43.2013
- PMID
- 23269995
- PMCID
- PMC3731919
- ISSN
- 0732-183X
- eISSN
- 1527-7755
- Grant note
- R01 CA129639 / NCI NIH HHS P30 ES005605 / NIEHS NIH HHS U01 CA083178 / NCI NIH HHS R01 AG014358 / NIA NIH HHS R01CA097397 / NCI NIH HHS R01 CA097397 / NCI NIH HHS R01CA114236 / NCI NIH HHS K05 CA136967 / NCI NIH HHS U01CA083178 / NCI NIH HHS R01CA129639 / NCI NIH HHS P30 CA008748 / NCI NIH HHS R01 CA114236 / NCI NIH HHS
- Language
- English
- Date published
- 02/01/2013
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995039102771
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