Journal article
Risk of cancer in retransplants compared to primary kidney transplants in the United States
Clinical transplantation, Vol.29(10), pp.944-950
10/2015
DOI: 10.1111/ctr.12601
PMCID: PMC4596781
PMID: 26255999
Abstract
Recipients of kidney transplantation have elevated risk of developing cancer. There are limited data on cancer risk in recipients of kidney retransplantation. We used data from the Transplant Cancer Match Study, which links the U.S. transplant registry with 15 cancer registries. Cancer incidence in recipients of kidney retransplantation and primary kidney transplants was compared utilizing Poisson regression, adjusting for demographic and medical characteristics. We assessed 109 224 primary recipients and 6621 retransplants. Compared to primary recipients, retransplants were younger (median age 40 vs. 46 yr), had higher PRA, and more often received induction with polyclonal antibodies (43% vs. 25%). A total of 5757 cancers were observed in primary recipients and 245 in retransplants. Overall cancer risk was similar in retransplants compared with primary recipients (incidence rate ratio [IRR] 1.06, 95% CI 0.93-1.20, adjusted for age, gender, race/ethnicity, PRA, and use of polyclonal induction). However, renal cell carcinoma (RCC) occurred in excess among retransplants (adjusted IRR 2.03, 95% CI 1.45-2.77), based on 514 cases in primary recipients and 43 cases in retransplants. Overall cancer risk did not differ in retransplants compared to primary recipients. Increased risk of RCC may be explained by the presence of acquired cystic kidney disease, which is more likely to develop with additional time with kidney disease and time spent on dialysis waiting for retransplantation.
Details
- Title: Subtitle
- Risk of cancer in retransplants compared to primary kidney transplants in the United States
- Creators
- Roberto S Kalil - Division of Nephrology, University of Iowa Carver College of Medicine, and Comprehensive Access and Delivery Research and Evaluation (CADRE) Center at the Iowa City VA Healthcare System, Iowa City, IA, USACharles F Lynch - College of Public Health, University of Iowa, Iowa City, IA, USAEric A Engels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
- Resource Type
- Journal article
- Publication Details
- Clinical transplantation, Vol.29(10), pp.944-950
- DOI
- 10.1111/ctr.12601
- PMID
- 26255999
- PMCID
- PMC4596781
- NLM abbreviation
- Clin Transplant
- ISSN
- 1399-0012
- eISSN
- 1399-0012
- Publisher
- Denmark
- Grant note
- N01PC35142 / NCI NIH HHS 5U58DP000824-04 / NCCDPHP CDC HHS U58DP000832 / NCCDPHP CDC HHS HHSN261201000024C / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS U58 DP000824 / NCCDPHP CDC HHS HHSN261201000036C / NCI NIH HHS HHSH234200537009C / PHS HHS U58DP003879 / NCCDPHP CDC HHS N01-PC-2013-00021 / NCI NIH HHS U58 DP003875 / NCCDPHP CDC HHS Z01 CP010150-09 / Intramural NIH HHS U58 DP003931 / NCCDPHP CDC HHS 5U58DP000812-03 / NCCDPHP CDC HHS N01PC35137 / NCI NIH HHS U58 DP000812 / NCCDPHP CDC HHS U58 DP000832 / NCCDPHP CDC HHS HHSN261201000035C / NCI NIH HHS U58 DP003879 / NCCDPHP CDC HHS HSN261201000032C / PHS HHS HHSH250201000018C / PHS HHS U58 DP000805 / NCCDPHP CDC HHS 5658DP000805-04 / NCCDPHP CDC HHS N01-PC-35143 / NCI NIH HHS 5U58DP003875-01 / NCCDPHP CDC HHS HHSN261201300021I / PHS HHS U58 DP000848 / NCCDPHP CDC HHS N01-PC-35137 / NCI NIH HHS HHSN261201000034C / NCI NIH HHS N01-PC-35142 / NCI NIH HHS N01PC35139 / NCI NIH HHS P30 CA086862 / NCI NIH HHS HHSN261201300021C / NCI NIH HHS HHSN261201000037C / NCI NIH HHS 5U58/DP003931-02 / NCCDPHP CDC HHS N01PC35143 / NCI NIH HHS N01-PC-35139 / NCI NIH HHS HHSN261201000026C / NCI NIH HHS U58 DP000848-04 / NCCDPHP CDC HHS HHSN261201000035I / NCI NIH HHS
- Language
- English
- Date published
- 10/2015
- Academic Unit
- Epidemiology
- Record Identifier
- 9983996093302771
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