Journal article
Risk of hypertension following perinatal adversity: IUGR and prematurity
Journal of endocrinology, Vol.242(1), pp.T21-T32
07/01/2019
DOI: 10.1530/JOE-18-0687
PMCID: PMC6594910
PMID: 30657741
Abstract
Consistent with the paradigm shifting observations of David Barker and colleagues that revealed a powerful relationship between decreased weight through 2 years of age and adult disease, intrauterine growth restriction (IUGR) and preterm birth are independent risk factors for the development of subsequent hypertension. Animal models have been indispensable in defining the mechanisms responsible for these associations and the potential targets for therapeutic intervention. Among the modifiable risk factors, micronutrient deficiency, physical immobility, exaggerated stress hormone exposure and deficient trophic hormone production are leading candidates for targeted therapies. With the strong inverse relationship seen between gestational age at delivery and the risk of hypertension in adulthood trumping all other major cardiovascular risk factors, improvements in neonatal care are required. Unfortunately, therapeutic breakthroughs have not kept pace with rapidly improving perinatal survival, and groundbreaking benchto-bedside studies are urgently needed to mitigate and ultimately prevent the tsunami of prematurity-related adult cardiovascular disease that may be on the horizon. This review highlights our current understanding of the developmental origins of hypertension and draws attention to the importance of increasing the availability of lactation consultants, nutritionists, pharmacists and physical therapists as critical allies in the battle that IUGR or premature infants are waging not just for survival but also for their future cardiometabolic health.
Details
- Title: Subtitle
- Risk of hypertension following perinatal adversity: IUGR and prematurity
- Creators
- Trassanee Chatmethakul - University of IowaRobert D. Roghair - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Journal of endocrinology, Vol.242(1), pp.T21-T32
- Publisher
- Bioscientifica Ltd
- DOI
- 10.1530/JOE-18-0687
- PMID
- 30657741
- PMCID
- PMC6594910
- ISSN
- 0022-0795
- eISSN
- 1479-6805
- Number of pages
- 12
- Grant note
- HL007485 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T35HL007485 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 07/01/2019
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354009302771
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