Risk of lip cancer after solid organ transplantation in the United States

Claudie Laprise; Elizabeth K Cahoon; Charles F Lynch; Amy R Kahn; Glenn Copeland; Lou Gonsalves; Margaret M Madeleine; Ruth M Pfeiffer; Eric A Engels

doi:10.1111/ajt.15052

Back

Risk of lip cancer after solid organ transplantation in the United States

Journal article

Open access

Peer reviewed

Risk of lip cancer after solid organ transplantation in the United States

Claudie Laprise, Elizabeth K Cahoon, Charles F Lynch, Amy R Kahn, Glenn Copeland, Lou Gonsalves, Margaret M Madeleine, Ruth M Pfeiffer and Eric A Engels

American journal of transplantation, Vol.19(1), pp.227-237

01/2019

DOI: 10.1111/ajt.15052

PMCID: PMC6310619

PMID: 30074684

Files and links (1)

url

https://doi.org/10.1111/ajt.15052View

Published (Version of record) Open Access

Abstract

Solid organ transplant recipients have an increased risk of lip cancer, but the reasons are uncertain. Using data from the Transplant Cancer Match Study, we describe the epidemiology of lip cancer among 261 500 transplant recipients in the United States. Two hundred thirty-one lip cancers were identified, corresponding to elevated risks for both invasive and in situ lip cancers (standardized incidence ratios of 15.3 and 26.2, respectively). Invasive lip cancer incidence was associated with male sex (adjusted incidence rate ratio [aIRR] 2.01, 95% CI 1.44-2.82), transplanted organ (0.33, 0.20-0.57, for liver transplants and 3.07, 1.96-4.81, for lung transplants, compared with kidney transplants), and racial/ethnic groups other than non-Hispanic whites (0.09, 0.04-0.2). In addition, incidence increased with age and during the first 3 years following transplant, and was higher in recipients prescribed cyclosporine/azathioprine maintenance therapy (aIRR 1.79, 95% CI 1.09-2.93, compared with use of tacrolimus/mycophenolate mofetil) and following a diagnosis of cutaneous squamous cell carcinoma (4.21, 2.69-0.94). The elevation in lip cancer incidence is consistent with an effect of immunosuppression. Notably, the very strong associations with white race and history of prior skin cancer point to an important role for ultraviolet radiation exposure, and cyclosporine and azathioprine may contribute as photosensitizing or DNA damaging agents.

United States

Humans

Middle Aged

Lip Neoplasms - epidemiology

Child, Preschool

Infant

Male

Transplant Recipients

Carcinoma, Squamous Cell - ethnology

Incidence

Carcinoma, Squamous Cell - diagnosis

Young Adult

Ethnic Groups

Immunosuppression - adverse effects

Adult

Female

Lip Neoplasms - ethnology

Child

Infant, Newborn

Carcinoma, Squamous Cell - epidemiology

Risk Factors

Postoperative Complications - diagnosis

Cyclosporine - adverse effects

Organ Transplantation - adverse effects

Adolescent

Lip Neoplasms - diagnosis

Immunosuppressive Agents - adverse effects

Aged

DNA Damage

Azathioprine - adverse effects

Details

Title: Subtitle: Risk of lip cancer after solid organ transplantation in the United States
Creators: Claudie Laprise - Division of Oral Health and Society, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
Elizabeth K Cahoon - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Charles F Lynch - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA
Amy R Kahn - New York State Cancer Registry, New York State Department of Health, Albany, NY, USA
Glenn Copeland - Michigan Department of Health and Human Services, Lansing, MI, USA
Lou Gonsalves - Connecticut Tumor Registry, Connecticut Department of Public Health, Hartford, CT, USA
Margaret M Madeleine - Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Ruth M Pfeiffer - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Eric A Engels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Resource Type: Journal article
Publication Details: American journal of transplantation, Vol.19(1), pp.227-237
DOI: 10.1111/ajt.15052
PMID: 30074684
PMCID: PMC6310619
NLM abbreviation: Am J Transplant
ISSN: 1600-6143
eISSN: 1600-6143
Publisher: United States
Grant note: HSN261201000032C / Minneapolis Medical Research Foundation N01PC35142 / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS U58 DP000824 / NCCDPHP CDC HHS N01-PC-2013-00021 / Minneapolis Medical Research Foundation HHSH250201000018C / Minneapolis Medical Research Foundation HHSN261201300021I / Minneapolis Medical Research Foundation HHSN261201000036C / NCI NIH HHS U58 DP003875 / NCCDPHP CDC HHS U58 DP003931 / NCCDPHP CDC HHS N01PC35137 / NCI NIH HHS U58 DP003921 / NCCDPHP CDC HHS HHSH234200537009C / Minneapolis Medical Research Foundation 5458DP003920 / Massachusetts Cancer Prevention and Control Cooperative Agreement HHSN261201000035C / NCI NIH HHS 5U58DP003921-03 / CDC HHS N01-PC-35139 / Minneapolis Medical Research Foundation N01-PC-35142 / Minneapolis Medical Research Foundation U58DP003933 / CDC HHS 5U58DP000824-04 / CDC HHS HHSN261201300011C / CCR NIH HHS 5U58DP003883-03 / CDC HHS U58 DP003933 / NCCDPHP CDC HHS HHSN261201300071C / NCI NIH HHS 6NU58DP006309 / CDC HHS 135506 / CDC HHS U58DP12-1205 3919-03 / Minneapolis Medical Research Foundation U58 DP003920 / NCCDPHP CDC HHS U58 DP000848-04 / Minneapolis Medical Research Foundation U58 DP000848 / NCCDPHP CDC HHS HHSN261201000034C / NCI NIH HHS HHSN2612013000171 / Minneapolis Medical Research Foundation N01PC35139 / NCI NIH HHS P30 CA086862 / NCI NIH HHS HHSN261201300021C / NCI NIH HHS HHSN261201300011I / NCI NIH HHS HHSN261201000037C / NCI NIH HHS 5U58DP003875-01 / CDC HHS HHSN261201800002I / Minneapolis Medical Research Foundation N01-PC-35143 / Minneapolis Medical Research Foundation N01PC35143 / NCI NIH HHS NU58DP003931-05-00 / CDC HHS N01-PC-35137 / Minneapolis Medical Research Foundation 1U58 DP000807-01 / Minneapolis Medical Research Foundation ZIA CP010150-17 / Intramural NIH HHS FRN: 135506 / CIHR U58 DP003883 / NCCDPHP CDC HHS HHSN261201000035I / NCI NIH HHS
Language: English
Date published: 01/2019
Academic Unit: Epidemiology
Record Identifier: 9983995177402771

Metrics

37 Record Views

17 Times Cited - Web of Science