Risk of lymphoma subtypes after solid organ transplantation in the United States

C A Clarke; L M Morton; C Lynch; R M Pfeiffer; E C Hall; T M Gibson; D D Weisenburger; O Martínez-Maza; S K Hussain; J Yang; E T Chang; E A Engels

doi:10.1038/bjc.2013.294

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Risk of lymphoma subtypes after solid organ transplantation in the United States

Journal article

Open access

Peer reviewed

Risk of lymphoma subtypes after solid organ transplantation in the United States

C A Clarke, L M Morton, C Lynch, R M Pfeiffer, E C Hall, T M Gibson, D D Weisenburger, O Martínez-Maza, S K Hussain, J Yang, …

British journal of cancer, Vol.109(1), pp.280-288

07/09/2013

DOI: 10.1038/bjc.2013.294

PMCID: PMC3708563

PMID: 23756857

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Abstract

Solid organ transplant recipients have high risk of lymphomas, including non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). A gap in our understanding of post-transplant lymphomas involves the spectrum and associated risks of their many histologic subtypes. We linked nationwide data on solid organ transplants from the US Scientific Registry of Transplant Recipients (1987-2008) to 14 state and regional cancer registries, yielding 791 281 person-years of follow-up for 19 distinct NHL subtypes and HL. We calculated standardised incidence ratios (SIRs) and used Poisson regression to compare SIRs by recipient age, transplanted organ, and time since transplantation. The risk varied widely across subtypes, with strong elevations (SIRs 10-100) for hepatosplenic T-cell lymphoma, Burkitt's lymphoma, NK/T-cell lymphoma, diffuse large B-cell lymphoma, and anaplastic large-cell lymphoma (both systemic and primary cutaneous forms). Moderate elevations (SIRs 2-4) were observed for HL and lymphoplasmacytic, peripheral T-cell, and marginal zone lymphomas, but SIRs for indolent lymphoma subtypes were not elevated. Generally, SIRs were highest for younger recipients (<20 years) and those receiving organs other than kidneys. Transplant recipients experience markedly elevated risk of a distinct spectrum of lymphoma subtypes. These findings support the aetiologic relevance of immunosuppression for certain subtypes and underscore the importance of detailed haematopathologic workup for transplant recipients with suspected lymphoma.

Lymphoma - epidemiology

United States - epidemiology

Humans

Middle Aged

Risk Factors

Child, Preschool

Infant

Male

Treatment Outcome

Incidence

Young Adult

Organ Transplantation - adverse effects

Adolescent

Aged, 80 and over

Adult

Female

Registries

Aged

Child

Details

Title: Subtitle: Risk of lymphoma subtypes after solid organ transplantation in the United States
Creators: C A Clarke - Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538-2334, USA. tina@cpic.org
L M Morton
C Lynch
R M Pfeiffer
E C Hall
T M Gibson
D D Weisenburger
O Martínez-Maza
S K Hussain
J Yang
E T Chang
E A Engels
Resource Type: Journal article
Publication Details: British journal of cancer, Vol.109(1), pp.280-288
DOI: 10.1038/bjc.2013.294
PMID: 23756857
PMCID: PMC3708563
NLM abbreviation: Br J Cancer
ISSN: 0007-0920
eISSN: 1532-1827
Publisher: England
Grant note: N01PC35142 / NCI NIH HHS 5U58DP000824-04 / NCCDPHP CDC HHS U58DP000832 / NCCDPHP CDC HHS HHSN261201000024C / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS U58 DP000824 / NCCDPHP CDC HHS HHSH234200537009C / PHS HHS N01PC54405 / NCI NIH HHS 5U58DP000812-03 / NCCDPHP CDC HHS HHSN261201000040I / NCI NIH HHS U58 DP000817 / NCCDPHP CDC HHS N01PC35137 / NCI NIH HHS 5U58/DP000808-05 / NCCDPHP CDC HHS U58 DP000812 / NCCDPHP CDC HHS 5U58DP000817-05 / NCCDPHP CDC HHS Intramural NIH HHS U58 DP000832 / NCCDPHP CDC HHS HHSN261201000035C / NCI NIH HHS HHSH250201000018C / PHS HHS U58 DP000805 / NCCDPHP CDC HHS 5658DP000805-04 / NCCDPHP CDC HHS N01-PC-35143 / NCI NIH HHS 1U58 DP000807-01 / NCCDPHP CDC HHS U58 DP000848 / NCCDPHP CDC HHS N01-PC-35137 / NCI NIH HHS U58 DP000808 / NCCDPHP CDC HHS HHSN261201000034C / NCI NIH HHS HHSN261201000040C / NCI NIH HHS N01-PC-54405 / NCI NIH HHS N01-PC-35142 / NCI NIH HHS N01PC35139 / NCI NIH HHS HHSN261201000037C / NCI NIH HHS U58DP000848-04 / NCCDPHP CDC HHS HHSN261201000032C / NCI NIH HHS N01PC35143 / NCI NIH HHS HHSN261201000027C / NCI NIH HHS N01-PC-35139 / NCI NIH HHS K07 CA140360 / NCI NIH HHS HHSN261201000026C / NCI NIH HHS HHSN261201000035I / NCI NIH HHS
Language: English
Date published: 07/09/2013
Academic Unit: Epidemiology; Community and Behavioral Health
Record Identifier: 9983995107102771

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