Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria

Rupal Shroff; Craig H. Syrop; William Davis; Bradley J. Van Voorhis; Anuja Dokras

doi:10.1016/j.fertnstert.2007.01.032

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Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria

Journal article

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Peer reviewed

Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria

Rupal Shroff, Craig H. Syrop, William Davis, Bradley J. Van Voorhis and Anuja Dokras

Fertility and sterility, Vol.88(5), pp.1389-1395

11/01/2007

DOI: 10.1016/j.fertnstert.2007.01.032

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Abstract

Objective To determine the risk of metabolic complications, primarily metabolic syndrome, in all polycystic ovary syndrome (PCOS) phenotypes compared with control subjects. Design Retrospective chart review. Setting University practice. Patient(s) Women with PCOS (Rotterdam definition; n = 258) and women without PCOS seen during the same time period for an annual exam used as controls (n = 110). Intervention(s) None. Main Outcome Measure(s) Metabolic syndrome. Result(s) Three PCOS phenotypes had a significantly higher prevalence of metabolic syndrome compared with the control subjects: oligomenorrhea/oligo-ovulation (O) + hyperandrogenism (H) + polycystic ovaries (P), age-adjusted odds ratio [OR] 6.3 (95% confidence interval 2.1–18.9); O+H, OR 7.8 (2.2–27.5); and H+P, OR 8.2 (2.3–29.3). There was no significant difference in the prevalence of metabolic syndrome between women with O+P and control subjects, even in obese women. The prevalence of insulin resistance and glucose intolerance was not significantly different between POCS phenotypes Conclusion(s) The risk of metabolic syndrome may vary among the four phenotypes of PCOS based on the Rotterdam criteria. This new information may be of relevance in counseling women with PCOS although larger studies may be needed to validate our findings.

Obstetrics and Gynecology

Details

Title: Subtitle: Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria
Creators: Rupal Shroff
Craig H. Syrop - University of Iowa
William Davis
Bradley J. Van Voorhis - University of Iowa
Anuja Dokras
Resource Type: Journal article
Publication Details: Fertility and sterility, Vol.88(5), pp.1389-1395
DOI: 10.1016/j.fertnstert.2007.01.032
ISSN: 0015-0282
Language: English
Date published: 11/01/2007
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9983557452702771

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