Journal article
Risk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies: analysis of the control arm of PATRICIA
The Journal of infectious diseases, Vol.210(4), pp.517-534
08/15/2014
DOI: 10.1093/infdis/jiu139
PMCID: PMC4111909
PMID: 24610876
Abstract
We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681).
Using Poisson regression, we compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15-25 years) in the control arm (DNA negative at baseline for the corresponding HPV type [HPV-16: n = 8193; HPV-18: n = 8463]).
High titers of naturally acquired HPV-16 antibodies and/or linear trend for increasing antibody levels were significantly associated with lower risk of incident and persistent infection, atypical squamous cells of undetermined significance or greater (ASCUS+), and cervical intraepithelial neoplasia grades 1/2 or greater (CIN1+, CIN2+). For HPV-18, although seropositivity was associated with lower risk of ASCUS+ and CIN1+, no association between naturally acquired antibodies and infection was demonstrated. Naturally acquired HPV-16 antibody levels of 371 (95% confidence interval [CI], 242-794), 204 (95% CI, 129-480), and 480 (95% CI, 250-5756) EU/mL were associated with 90% reduction of incident infection, 6-month persistent infection, and ASCUS+, respectively.
Naturally acquired antibodies to HPV-16, and to a lesser extent HPV-18, are associated with some reduced risk of subsequent infection and cervical abnormalities associated with the same HPV type.
Details
- Title: Subtitle
- Risk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies: analysis of the control arm of PATRICIA
- Creators
- Xavier Castellsagué - Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia, IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Catalonia, SpainPaulo Naud - Department of Gynecology and Obstetrics, Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, BrazilSong-Nan Chow - Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, TaiwanCosette M Wheeler - Department of Pathology and Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, AlbuquerqueMaria Julieta V Germar - Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippine General Hospital, Manila, The PhilippinesMatti Lehtinen - University of Tampere, School of Public Health, TampereJorma Paavonen - Department of Obstetrics and Gynaecology, University of Helsinki, FinlandUnnop Jaisamrarn - Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandSuzanne M Garland - Department of Microbiology and Infectious Diseases, The Royal Women's Hospital Department of Microbiology, The Royal Children's Hospital, Parkville/Murdoch Childrens Research Institute Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, AustraliaJorge Salmerón - Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Morelos, MexicoDan Apter - Family Federation of Finland, Sexual Health Clinic, Helsinki, FinlandHenry Kitchener - Manchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, St Mary's Hospital, Manchester, United KingdomJulio C Teixeira - Departamento de Tocoginecologia da Unicamp, University of Campinas, Sao Paulo, BrazilS Rachel Skinner - Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, Western Australia Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead, Sydney, New South Wales, AustraliaGenara Limson - College of Medicine, University of the Philippines, Philippine General Hospital, Makati Medical Centre, Makati City, The PhilippinesAnne Szarewski - Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, United KingdomBarbara Romanowski - Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, CanadaFred Y Aoki - Department of Medical Microbiology, University of Manitoba, Winnipeg, CanadaTino F Schwarz - Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, GermanyWilly A J Poppe - Department of Gynaecology, University Hospital KU Leuven Gasthuisberg, BelgiumF Xavier Bosch - Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia, IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Catalonia, Spain Network on Cooperative Cancer Research, RTICC, Catalonia, SpainNewton S de Carvalho - Department of Gynecology and Obstetrics, Federal University of Paraná, Infectious Diseases in Gynecology and Obstetrics Sector, Curitiba, BrazilKlaus Peters - Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg, GermanyWiebren A A Tjalma - Multidisciplinary Breast Clinic-Gynecologic Oncology, Antwerp University Hospital, University of Antwerp, BelgiumMahboobeh Safaeian - Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, Rockville, MarylandAlice Raillard - 4Clinics, Paris, FranceDominique Descamps - GlaxoSmithKline Vaccines, Wavre, BelgiumFrank Struyf - GlaxoSmithKline Vaccines, Wavre, BelgiumGary Dubin - GlaxoSmithKline Vaccines, King of Prussia, PennsylvaniaDominique Rosillon - GlaxoSmithKline Vaccines, Wavre, BelgiumLaurence Baril - GlaxoSmithKline Vaccines, Wavre, Belgium
- Contributors
- J Stapleton (Contributor) - University of Iowa, Internal Medicine
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.210(4), pp.517-534
- DOI
- 10.1093/infdis/jiu139
- PMID
- 24610876
- PMCID
- PMC4111909
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 08/15/2014
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094658502771
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