Risk of pancreatic cancer among individuals with a family history of cancer of the pancreas

Parviz Ghadirian; Geoffrey Liu; Steven Gallinger; Beverly Schmocker; Anne-Josee Paradis; Geeta Lal; Jean-Sebastien Brunet; William D Foulkes; Steven A Narod

doi:10.1002/ijc.10123

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Risk of pancreatic cancer among individuals with a family history of cancer of the pancreas

Journal article

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Risk of pancreatic cancer among individuals with a family history of cancer of the pancreas

Parviz Ghadirian, Geoffrey Liu, Steven Gallinger, Beverly Schmocker, Anne-Josee Paradis, Geeta Lal, Jean-Sebastien Brunet, William D Foulkes and Steven A Narod

International journal of cancer, Vol.97(6), pp.807-810

2002

DOI: 10.1002/ijc.10123

PMID: 11857359

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Abstract

In a hospital based case-control study of pancreatic cancer in Ontario and Quebec, a total of 174 incident pancreatic cancer cases and 136 healthy controls were compared for their family history of cancer. Information regarding the ages and sites of cancer was taken for 966 first-degree relatives of the cancer cases and for 903 first-degree relatives of the controls. A total of 150 cancer cases were reported among the relatives of the cases, compared to 122 cases among the relatives of the controls (relative risk 1.15; p = 0.23). Pancreatic cancer was the only site statistically in excess in the case relatives, compared to the control relatives (relative risk = 5.0; p = 0.01). The lifetime risk of pancreatic cancer was 4.7% for the first-degree relatives of the pancreatic cancer cases. The risk was 7.2% for relatives of cases diagnosed before age 60, and was 12.3% for relatives of patients with multiple primary cancers (all ages). These individuals comprise a high-risk group for pancreatic cancer and might benefit from enhanced surveillance or chemoprevention. Familial site-specific pancreatic cancer appears to be a distinct genetic entity, but contributes only modestly to the total burden of pancreatic cancer. © 2002 Wiley-Liss, Inc.

Tumors

Biological and medical sciences

Gastroenterology. Liver. Pancreas. Abdomen

Liver. Biliary tract. Portal circulation. Exocrine pancreas

Medical sciences

Details

Title: Subtitle: Risk of pancreatic cancer among individuals with a family history of cancer of the pancreas
Creators: Parviz Ghadirian - Hôtel-Dieu de Montréal
Geoffrey Liu - University of Toronto
Steven Gallinger - University of Toronto
Beverly Schmocker - University of Toronto
Anne-Josee Paradis - McGill University Health Centre
Geeta Lal - University of Toronto
Jean-Sebastien Brunet - Algorithme Pharma
William D Foulkes - McGill University Health Centre
Steven A Narod - University of Toronto
Resource Type: Journal article
Publication Details: International journal of cancer, Vol.97(6), pp.807-810
DOI: 10.1002/ijc.10123
PMID: 11857359
NLM abbreviation: Int J Cancer
ISSN: 0020-7136
eISSN: 1097-0215
Publisher: Wiley-Liss
Language: English
Date published: 2002
Academic Unit: Stead Family Department of Pediatrics; Surgery
Record Identifier: 9984322805802771

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