Journal article
Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives
International journal of epidemiology, Vol.47(2), pp.473-483
04/01/2018
DOI: 10.1093/ije/dyx269
PMID: 29329392
Abstract
Family history (FH) of pancreatic cancer (PC) has been associated with an increased risk of PC, but little is known regarding the role of inherited/environmental factors or that of FH of other comorbidities in PC risk. We aimed to address these issues using multiple methodological approaches.
Case-control study including 1431 PC cases and 1090 controls and a reconstructed-cohort study (N = 16 747) made up of their first-degree relatives (FDR). Logistic regression was used to evaluate PC risk associated with FH of cancer, diabetes, allergies, asthma, cystic fibrosis and chronic pancreatitis by relative type and number of affected relatives, by smoking status and other potential effect modifiers, and by tumour stage and location. Familial aggregation of cancer was assessed within the cohort using Cox proportional hazard regression.
FH of PC was associated with an increased PC risk [odds ratio (OR) = 2.68; 95% confidence interval (CI): 2.27-4.06] when compared with cancer-free FH, the risk being greater when ≥ 2 FDRs suffered PC (OR = 3.88; 95% CI: 2.96-9.73) and among current smokers (OR = 3.16; 95% CI: 2.56-5.78, interaction FHPC*smoking P-value = 0.04). PC cumulative risk by age 75 was 2.2% among FDRs of cases and 0.7% in those of controls [hazard ratio (HR) = 2.42; 95% CI: 2.16-2.71]. PC risk was significantly associated with FH of cancer (OR = 1.30; 95% CI: 1.13-1.54) and diabetes (OR = 1.24; 95% CI: 1.01-1.52), but not with FH of other diseases.
The concordant findings using both approaches strengthen the notion that FH of cancer, PC or diabetes confers a higher PC risk. Smoking notably increases PC risk associated with FH of PC. Further evaluation of these associations should be undertaken to guide PC prevention strategies.
Details
- Title: Subtitle
- Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives
- Creators
- J Huang - Karolinska InstitutetE Molina-Montes - Spanish National Cancer Research Center (CNIO), Genetic and Molecular Epidemiology Group, Madrid, and CIBERONC, SpainP Gomez-Rubio - Spanish National Cancer Research Center (CNIO), Genetic and Molecular Epidemiology Group, Madrid, and CIBERONC, SpainM Márquez - Spanish National Cancer Research Center (CNIO), Genetic and Molecular Epidemiology Group, Madrid, and CIBERONC, SpainM Rava - Spanish National Cancer Research Center (CNIO), Genetic and Molecular Epidemiology Group, Madrid, and CIBERONC, SpainM Löhr - Karolinska Institutet and University Hospital, Gastrocentrum, Stockholm, SwedenC W Michalski - University of Heidelberg, Department of Surgery, Heidelberg, GermanyX Molero - Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, and CIBEREHD, SpainA Farré - Hospital de la Santa Creu i Sant Pau, Department of Gastroenterology, Barcelona, SpainJ Perea - University Hospital 12 de Octubre, Department of Surgery, Madrid, SpainW Greenhalf - Royal Liverpool University Hospital, Department of Molecular and Clinical Cancer Medicine, Liverpool, UKL Ilzarbe - Hospital del Mar-Parc de Salut Mar, Barcelona, SpainM O'Rorke - Queen's University Belfast, Centre for Public Health, Belfast, UKA Tardón - Instituto Universitario de Oncología del Principado de Asturias, Department of Medicine, Oviedo, and CIBERESP, SpainT Gress - University Hospital of Giessen and Marburg, Department of Gastroenterology, Marburg, GermanyV M Barberà - General University Hospital of Elche, Molecular Genetics Laboratory, Elche, SpainT Crnogorac-Jurcevic - Barts Cancer Institute, Centre for Molecular Oncology, Queen Mary University of London, London, UKE Domínguez-Muñoz - University Clinical Hospital of Santiago de Compostela, Department of Gastroenterology, Santiago de Compostela, SpainL Muñoz-Bellvís - Salamanca University Hospital, General and Digestive Surgery Department, Salamanca, SpainJ Balsells - Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, and CIBEREHD, SpainE Costello - Royal Liverpool University Hospital, Department of Molecular and Clinical Cancer Medicine, Liverpool, UKM Iglesias - Hospital del Mar-Parc de Salut Mar, Barcelona, SpainJ Kleeff - Martin-Luther-University Halle-Wittenberg, Department of Visceral, Vascular and Endocrine Surgery, Halle (Saale), GermanyBo Kong - Technical University of Munich, Department of Surgery, Munich, GermanyJ Mora - Hospital de la Santa Creu i Sant Pau, Department of Gastroenterology, Barcelona, SpainL Murray - Queen's University Belfast, Centre for Public Health, Belfast, UKD O'Driscoll - National Cancer Registry Ireland and HRB Clinical Research Facility, University College Cork, Cork, IrelandI Poves - Hospital del Mar-Parc de Salut Mar, Barcelona, SpainA Scarpa - ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, ItalyW Ye - Karolinska Institutet and University Hospital, Gastrocentrum, Stockholm, SwedenM Hidalgo - Madrid-Norte-Sanchinarro Hospital, Madrid, SpainL Sharp - Newcastle University, Institute of Health and Society, Newcastle upon Tyne, UKA Carrato - Ramón y Cajal University Hospital, Department of Oncology, IRYCIS, Alcala University, Madrid, and CIBERONC, SpainF X Real - Spanish National Cancer Research Centre (CNIO), Epithelial Carcinogenesis Group, Madrid, Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, and CIBERONC, SpainN Malats - Spanish National Cancer Research Center (CNIO), Genetic and Molecular Epidemiology Group, Madrid, and CIBERONC, SpainPanGenEU Study Investigators
- Resource Type
- Journal article
- Publication Details
- International journal of epidemiology, Vol.47(2), pp.473-483
- Publisher
- England
- DOI
- 10.1093/ije/dyx269
- PMID
- 29329392
- ISSN
- 1464-3685
- eISSN
- 1464-3685
- Grant note
- 15-0391 / Worldwide Cancer Research
- Language
- English
- Date published
- 04/01/2018
- Academic Unit
- Epidemiology; Pathology
- Record Identifier
- 9983996187502771
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