Journal article
Risk of pre-eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case–control study
BJOG : an international journal of obstetrics and gynaecology, Vol.128(1), pp.55-65
01/01/2021
DOI: 10.1111/1471-0528.16441
PMCID: PMC7736250
PMID: 32741103
Abstract
Objective
To assess whether women with a genetic predisposition to medical conditions known to increase pre-eclampsia risk have an increased risk of pre-eclampsia in pregnancy.
Design
Case–control study.
Setting and population
Pre-eclampsia cases (n = 498) and controls (n = 1864) in women of European ancestry from five US sites genotyped on a cardiovascular gene-centric array.
Methods
Significant single-nucleotide polymorphisms (SNPs) from 21 traits in seven disease categories (cardiovascular, inflammatory/autoimmune, insulin resistance, liver, obesity, renal and thrombophilia) with published genome-wide association studies (GWAS) were used to create a genetic instrument for each trait. Multivariable logistic regression was used to test the association of each continuous scaled genetic instrument with pre-eclampsia. Odds of pre-eclampsia were compared across quartiles of the genetic instrument and evaluated for significance.
Details
- Title: Subtitle
- Risk of pre-eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case–control study
- Creators
- K. J. Gray - Brigham and Women's HospitalV. P. Kovacheva - Brigham and Women's HospitalH. Mirzakhani - Massachusetts General HospitalA. C. Bjonnes - Massachusetts General HospitalB. Almoguera - Children's Hospital of PhiladelphiaM. L. Wilson - University of Southern CaliforniaS. A. Ingles - University of Southern CaliforniaC. J. Lockwood - University of South FloridaH. Hakonarson - Children's Hospital of PhiladelphiaT. F. McElrath - Brigham and Women's HospitalJ. C. Murray - University of IowaE. R. Norwitz - Tufts Medical CenterS. A. Karumanchi - Beth Israel Deaconess Medical CenterB. T. Bateman - Massachusetts General HospitalB. J. Keating - University of PennsylvaniaR. Saxena - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- BJOG : an international journal of obstetrics and gynaecology, Vol.128(1), pp.55-65
- DOI
- 10.1111/1471-0528.16441
- PMID
- 32741103
- PMCID
- PMC7736250
- NLM abbreviation
- BJOG
- ISSN
- 1470-0328
- eISSN
- 1471-0528
- Number of pages
- 11
- Grant note
- Howard Hughes Medical Institute (100000011) GlaxoSmithKline (http://data.elsevier.com/vocabulary/SciValFunders/100004330) NxPrenatal Society for Obstetric Anesthesia and Perinatology Gertie Marx Research 20‐FY03‐30; 21‐FY05‐1250 / March of Dimes Foundation (http://data.elsevier.com/vocabulary/SciValFunders/100000912) K08 HL146963 / National Institutes of Health (100000002) K12 HD051959 BIRCWH / National Institutes of Health (100000002) T32 HL007427 / National Institutes of Health (100000002) Howard Hughes Medical Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000011) K01HL146977; L30 HL129467; R21 HD046624 / National Heart, Lung, and Blood Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000050)
- Language
- English
- Date published
- 01/01/2021
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9985035880802771
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