Risk of prematurity and infant morbidity and mortality by maternal fertility status and plurality

Barbara Luke; Morton B Brown; Ethan Wantman; David B Seifer; Amy T Sparks; Paul C Lin; Kevin J Doody; Bradley J Van Voorhis; Logan G Spector

doi:10.1007/s10815-018-1333-z

Back

Risk of prematurity and infant morbidity and mortality by maternal fertility status and plurality

Journal article

Open access

Peer reviewed

Risk of prematurity and infant morbidity and mortality by maternal fertility status and plurality

Barbara Luke, Morton B Brown, Ethan Wantman, David B Seifer, Amy T Sparks, Paul C Lin, Kevin J Doody, Bradley J Van Voorhis and Logan G Spector

Journal of assisted reproduction and genetics, Vol.36(1), pp.121-138

01/2019

DOI: 10.1007/s10815-018-1333-z

PMCID: PMC6338589

PMID: 30328574

Files and links (1)

url

https://europepmc.org/articles/pmc6338589View

Published (Version of record) Open Access

Abstract

To evaluate the risk of prematurity and infant mortality by maternal fertility status, and for in vitro fertilization (IVF) pregnancies, by oocyte source and embryo state combinations. Women in 14 States who had IVF-conceived live births during 2004-13 were linked to their infant's birth and death certificates; a 10:1 sample of non-IVF births was selected for comparison; those with an indication of infertility treatment on the birth certificate were categorized as subfertile, all others were categorized as fertile. Risks were modeled separately for the fertile/subfertile/IVF (autologous-fresh only) group and for the IVF group by oocyte source-embryo state combinations, using logistic regression, and reported as adjusted odds ratios (AORs) and 95% confidence intervals (CI). The study population included 2,474,195 pregnancies. Placental complications (placenta previa, abruptio placenta, and other excessive bleeding) and prematurity were both increased with pregestational and gestational diabetes and hypertension, among subfertile and IVF groups, and in IVF pregnancies using donor oocytes. Both subfertile and IVF pregnancies were at risk for prematurity and NICU admission; IVF infants were also at risk for small-for-gestation birthweight, and subfertile infants had greater risks for neonatal and infant death. Within the IVF group, pregnancies with donor oocytes and/or thawed embryos were at greater risk of large-for-gestation birthweight, and pregnancies with thawed embryos were at greater risk of neonatal and infant death. Prematurity was associated with placental complications, diabetes and hypertension, subfertility and IVF groups, and in IVF pregnancies, donor oocytes and/or thawed embryos.

Fertilization in Vitro - adverse effects

United States - epidemiology

Infant, Newborn, Diseases - epidemiology

Pregnancy, Multiple

Placenta Diseases - epidemiology

Humans

Risk Factors

Infant, Newborn, Diseases - mortality

Infertility - complications

Placenta Diseases - mortality

Premature Birth - epidemiology

Pregnancy

Young Adult

Maternal Age

Fertility

Adolescent

Adult

Female

Infant, Newborn

Details

Title: Subtitle: Risk of prematurity and infant morbidity and mortality by maternal fertility status and plurality
Creators: Barbara Luke - Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, 965 Fee Road, East Fee Hall, Room 628, East Lansing, MI, USA. lukeb@msu.edu
Morton B Brown - Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA
Ethan Wantman - Redshift Technologies, Inc., New York, NY, USA
David B Seifer - Yale Fertility, Yale School of Medicine, New Haven, CT, USA
Amy T Sparks - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USA
Paul C Lin - Seattle Reproductive Medicine, Seattle, WA, USA
Kevin J Doody - Center for Assisted Reproduction, Bedford, TX, USA
Bradley J Van Voorhis - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USA
Logan G Spector - Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
Resource Type: Journal article
Publication Details: Journal of assisted reproduction and genetics, Vol.36(1), pp.121-138
DOI: 10.1007/s10815-018-1333-z
PMID: 30328574
PMCID: PMC6338589
NLM abbreviation: J Assist Reprod Genet
ISSN: 1573-7330
eISSN: 1573-7330
Publisher: Netherlands
Grant note: R01 CA151973 / NCI NIH HHS R01CA151973 / National Cancer Institute P2C HD041023 / NICHD NIH HHS R01 HD084377 / NICHD NIH HHS
Language: English
Date published: 01/2019
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9983931821002771

Metrics

30 Record Views

24 Times Cited - Web of Science