Risk of second primary malignancy in patients with primary myelofibrosis: a SEER database study

Utsav Joshi; Adheesh Bhattarai; Suman Gaire; Simrat Gill; Vishakha Agrawal; Sumeet Kumar Yadav; Soon Khai Low; Prajwal Dhakal; Vijaya Raj Bhatt; Peter A. Kouides

doi:10.1080/10428194.2022.2123227

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Risk of second primary malignancy in patients with primary myelofibrosis: a SEER database study

Journal article

Peer reviewed

Risk of second primary malignancy in patients with primary myelofibrosis: a SEER database study

Utsav Joshi, Adheesh Bhattarai, Suman Gaire, Simrat Gill, Vishakha Agrawal, Sumeet Kumar Yadav, Soon Khai Low, Prajwal Dhakal, Vijaya Raj Bhatt and Peter A. Kouides

Leukemia & lymphoma, Vol.63(14), pp.3456-3461

12/2022

DOI: 10.1080/10428194.2022.2123227

PMID: 36120968

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Abstract

Prior studies report a greater incidence of second primary malignancy (SPM) among patients with myeloproliferative neoplasms, although the true risk in primary myelofibrosis (PMF) has not been elucidated. We utilized the Surveillance, Epidemiology, and End Results database to evaluate the risk of SPM in PMF patients and analyzed the effects of sociodemographic factors on the risk of SPM. Out of 5273 patients, 385 patients (7.30%) developed SPM. SPM occurred at SIR of 1.95 (95% CI 1.76-2.15) and AER of 149.01 per 10,000 population. A significantly higher incidence of melanoma (SIR 1.76, 95% CI 1.01-2.86), lymphoma (SIR 3.38, 95% CI 2.28-4.83), and leukemia (SIR 27.19, 95% CI 23.09-31.81) was observed. The risk was significantly higher in patients ≤60 years, males, chemotherapy recipients, within 5 years of PMF diagnosis, and for PMF diagnosed after 2009.

Leukemia

incidence

melanoma

Primary myelofibrosis

second primary malignancy

Details

Title: Subtitle: Risk of second primary malignancy in patients with primary myelofibrosis: a SEER database study
Creators: Utsav Joshi - Rochester General Hospital
Adheesh Bhattarai - Tribhuvan University Teaching Hospital
Suman Gaire - Mount Sinai Hospital
Simrat Gill - Rochester General Hospital
Vishakha Agrawal - Tribhuvan University Teaching Hospital
Sumeet Kumar Yadav - Mayo Clinic Health System
Soon Khai Low - Rochester General Hospital
Prajwal Dhakal - University of Iowa
Vijaya Raj Bhatt - University of Nebraska Medical Center
Peter A. Kouides - University of Rochester
Resource Type: Journal article
Publication Details: Leukemia & lymphoma, Vol.63(14), pp.3456-3461
DOI: 10.1080/10428194.2022.2123227
PMID: 36120968
NLM abbreviation: Leuk Lymphoma
ISSN: 1042-8194
eISSN: 1029-2403
Publisher: Taylor & Francis
Language: English
Electronic publication date: 09/17/2022
Date published: 12/2022
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984359779202771

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