Journal article
Risk of small intestinal bacterial overgrowth in patients receiving proton pump inhibitors versus proton pump inhibitors plus prokinetics
JGH open, Vol.2(2), pp.47-53
04/02/2018
DOI: 10.1002/jgh3.12045
PMCID: PMC6206996
PMID: 30483563
Abstract
Background and Aim: Intestinal dysmotility is considered a risk factor for small intestinal bacterial overgrowth (SIBO). Prokinetics improve intestinal motility and are often prescribed with proton pump inhibitors (PPIs) in patients with gastroesophageal reflux disease (GERD) and/or functional dyspepsia. The present study aimed to evaluate the prevalence of SIBO and the orocecal transit time (OCTT) in patients taking PPI compared with those taking PPI plus prokinetics. Methods: The study is a single-center, cross-sectional study. Enrolled patients (with age > 12 years) were divided into two groups: patients taking PPIs for more than 3 months (Group A) and those taking PPIs with prokinetics for more than 3 months (Group B) for various indications. Lactulose breath test (LBT) for OCTT and glucose breath test (GBT) for SIBO were conducted for all patients. Results: Of the 147 enrolled patients, SIBO was documented in 13.2% patients in Group A versus 1.8% in Group B, P = 0.018. Median OCTT in Group A was 130 (105–160) min compared with 120 (92.5–147.5) min in Group B (P = 0.010). Median OCTT among SIBO-positive patients was 160 (140–172.5) min compared with SIBO-negative patients, where it was 120 (103.75–150) min (P = 0.002). The duration and type of PPI used were not associated with the occurrence of SIBO in our study. Conclusion: The use of prokinetics in patients on PPI may reduce the risk of SIBO by enhancing intestinal motility and may reduce SIBO risk associated with long-term PPI use.
Details
- Title: Subtitle
- Risk of small intestinal bacterial overgrowth in patients receiving proton pump inhibitors versus proton pump inhibitors plus prokinetics
- Creators
- Pruthvi C Revaiah - Postgraduate Institute of Medical Education and ResearchRakesh Kochhar - Post Graduate Institute of Medical Education and ResearchSurinder V Rana - Postgraduate Institute of Medical Education and ResearchNeha Berry - Post Graduate Institute of Medical Education and ResearchMunish Ashat - Post Graduate Institute of Medical Education and ResearchNarendra Dhaka - Post Graduate Institute of Medical Education and ResearchY Rami Reddy - Postgraduate Institute of Medical Education and ResearchSaroj K Sinha - Post Graduate Institute of Medical Education and Research
- Resource Type
- Journal article
- Publication Details
- JGH open, Vol.2(2), pp.47-53
- Publisher
- Wiley Publishing Asia Pty Ltd
- DOI
- 10.1002/jgh3.12045
- PMID
- 30483563
- PMCID
- PMC6206996
- ISSN
- 2397-9070
- eISSN
- 2397-9070
- Alternative title
- Small intestinal bacterial overgrowth
- Language
- English
- Date published
- 04/02/2018
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359762502771
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