Journal article
Risk of total and aggressive prostate cancer and pesticide use in the Agricultural Health Study
American journal of epidemiology, Vol.177(1), pp.59-74
01/01/2013
DOI: 10.1093/aje/kws225
PMCID: PMC3590039
PMID: 23171882
Abstract
Because pesticides may operate through different mechanisms, the authors studied the risk of prostate cancer associated with specific pesticides in the Agricultural Health Study (1993-2007). With 1,962 incident cases, including 919 aggressive prostate cancers among 54,412 applicators, this is the largest study to date. Rate ratios and 95% confidence intervals were calculated by using Poisson regression to evaluate lifetime use of 48 pesticides and prostate cancer incidence. Three organophosphate insecticides were significantly associated with aggressive prostate cancer: fonofos (rate ratio (RR) for the highest quartile of exposure (Q4) vs. nonexposed = 1.63, 95% confidence interval (CI): 1.22, 2.17; P(trend) < 0.001); malathion (RR for Q4 vs. nonexposed = 1.43, 95% CI: 1.08, 1.88; P(trend) = 0.04); and terbufos (RR for Q4 vs. nonexposed = 1.29, 95% CI: 1.02, 1.64; P(trend) = 0.03). The organochlorine insecticide aldrin was also associated with increased risk of aggressive prostate cancer (RR for Q4 vs. nonexposed = 1.49, 95% CI: 1.03, 2.18; P(trend) = 0.02). This analysis has overcome several limitations of previous studies with the inclusion of a large number of cases with relevant exposure and detailed information on use of specific pesticides at 2 points in time. Furthermore, this is the first time specific pesticides are implicated as risk factors for aggressive prostate cancer.
Details
- Title: Subtitle
- Risk of total and aggressive prostate cancer and pesticide use in the Agricultural Health Study
- Creators
- Stella Koutros - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8115, MSC 7240, Rockville, MD 20852, USA. KoutrosS@mail.nih.govLaura E Beane FreemanJay H LubinSonya L HeltsheGabriella AndreottiKathryn Hughes BarryCurt T DellaValleJane A HoppinDale P SandlerCharles F LynchAaron BlairMichael C R Alavanja
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.177(1), pp.59-74
- Publisher
- United States
- DOI
- 10.1093/aje/kws225
- PMID
- 23171882
- PMCID
- PMC3590039
- ISSN
- 1476-6256
- eISSN
- 1476-6256
- Grant note
- P30 ES005605 / NIEHS NIH HHS Z01 CP010119 / Intramural NIH HHS Z01ES0490300 / NIEHS NIH HHS
- Language
- English
- Date published
- 01/01/2013
- Academic Unit
- Epidemiology
- Record Identifier
- 9983996091802771
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