Journal article
Risks of Long-Term Psychiatric Disease in Women with a History of Primary Infertility: A Historical Cohort Study
Psychiatric quarterly, Vol.95(4), pp.643-655
12/01/2024
DOI: 10.1007/s11126-024-10095-6
PMID: 39382788
Abstract
To examine the risks of long-term de novo psychiatric disease in women with primary infertiltiy compared to age-matched referrent women. Retrospective, population-based cohort of 1,001 women with primary infertility and 1,001 age-matched (+/- 1 year) referent women aged 18-50. The "index date" was date of first clinical note for infertility and included visits fromJanuary 1, 1980 to December 31, 1999. Baseline characteristics were collected by chart review. Outcome data was evaluated through December 31, 2020. Primary outcomes were baseline prevalence and de novo rates of subsequent psychiatric disorders including depression, anxiety, bipolar disorder, substance abuse, suicidality, and somatization evaluated by Cox proportional hazards modeling. Among women with primary infertility and referent women, the median duration of follow-up was 23.7 years. The risk of de novo psychiatric disorders was not significantly different between groups. Additionally, the risk of de novo psychiatric disorders did not significantly differ between those with isolated male factor versus isolated female factor infertility. Among women with primary infertility, the cumulative incidence of de novo depression and anxiety was significantly higher among women diagnosed with primary infertility in the 1990s compared to the 1980s. Women with primary infertility, in a historical population-based cohort, do not have a significantly different long-term risk of de novo psychiatric diagnoses compared to age-matched referent women. Our findings support the notion that infertility diagnosis and treatment present an acute period of stress and for some psychologic distress, neither of which persist or increase the risk for development of future psychiatric disease.
Details
- Title: Subtitle
- Risks of Long-Term Psychiatric Disease in Women with a History of Primary Infertility: A Historical Cohort Study
- Creators
- Alessandra J. Ainsworth - Mayo ClinicEmily Sadecki - Mayo Clinic in ArizonaLauren M. Kendall Rauchfuss - Mayo ClinicHannah K. Betcher - Mayo ClinicYulian Zhao - Mayo ClinicCarin Y. Smith - Mayo Clinic in FloridaElizabeth A. Stewart - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Psychiatric quarterly, Vol.95(4), pp.643-655
- DOI
- 10.1007/s11126-024-10095-6
- PMID
- 39382788
- NLM abbreviation
- Psychiatr Q
- ISSN
- 0033-2720
- eISSN
- 1573-6709
- Publisher
- Springer Nature
- Number of pages
- 13
- Grant note
- RO1AG034676 / National Institute on Aging of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Language
- English
- Date published
- 12/01/2024
- Academic Unit
- Family and Community Medicine
- Record Identifier
- 9984961047102771
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