Journal article
Roadmap for an imaging and modelling paediatric study in rural NZ
Frontiers in physiology, Vol.14, p.1104838
03/10/2023
DOI: 10.3389/fphys.2023.1104838
PMCID: PMC10036853
PMID: 36969588
Abstract
Our study methodology is motivated from three disparate needs: one, imaging studies have existed in silo and study organs but not across organ systems; two, there are gaps in our understanding of paediatric structure and function; three, lack of representative data in New Zealand. Our research aims to address these issues in part, through the combination of magnetic resonance imaging, advanced image processing algorithms and computational modelling. Our study demonstrated the need to take an organ-system approach and scan multiple organs on the same child. We have pilot tested an imaging protocol to be minimally disruptive to the children and demonstrated state-of-the-art image processing and personalized computational models using the imaging data. Our imaging protocol spans brain, lungs, heart, muscle, bones, abdominal and vascular systems. Our initial set of results demonstrated child-specific measurements on one dataset. This work is novel and interesting as we have run multiple computational physiology workflows to generate personalized computational models. Our proposed work is the first step towards achieving the integration of imaging and modelling improving our understanding of the human body in paediatric health and disease.
Details
- Title: Subtitle
- Roadmap for an imaging and modelling paediatric study in rural NZ
- Creators
- Haribalan Kumar - University of AucklandRobby Green - Medical Research Institute of New ZealandDaniel M. Cornfeld - University of AucklandPaul Condron - Medical Research Institute of New ZealandTaylor Emsden - University of AucklandAyah Elsayed - Auckland University of TechnologyDebbie Zhao - University of AucklandKat Gilbert - University of AucklandMartyn P. Nash - Medical Research Institute of New ZealandAlys R. Clark - University of AucklandMerryn H. Tawhai - University of AucklandKelly Burrowes - University of AucklandRinki Murphy - University of AucklandMaryam Tayebi - University of AucklandJosh McGeown - Medical Research Institute of New ZealandEryn Kwon - University of AucklandVickie Shim - University of AucklandAlan Wang - University of AucklandJulie Choisne - University of AucklandLaura Carman - University of AucklandThor Besier - University of AucklandGeoffrey Handsfield - University of AucklandThiranja Prasad Babarenda Gamage - , , , , , , , , , , , , , , , , , , ,Jiantao Shen - University of AucklandGonzalo Maso Talou - , , , , , , , , , , , , , , , , , , ,Soroush Safaei - University of AucklandJerome J. Maller - Monash Alfred Psychiatry Research centreDavidson Taylor - Medical Research Institute of New ZealandLeigh Potter - Medical Research Institute of New ZealandSamantha J. Holdsworth - Medical Research Institute of New ZealandGraham A. Wilson - Medical Research Institute of New Zealand
- Resource Type
- Journal article
- Publication Details
- Frontiers in physiology, Vol.14, p.1104838
- DOI
- 10.3389/fphys.2023.1104838
- PMID
- 36969588
- PMCID
- PMC10036853
- NLM abbreviation
- Front Physiol
- ISSN
- 1664-042X
- eISSN
- 1664-042X
- Publisher
- Frontiers Media S.A
- Alternative title
- Kumar et al
- Language
- English
- Date published
- 03/10/2023
- Academic Unit
- Radiology
- Record Identifier
- 9984848499802771
Metrics
2 Record Views