Robust Identification of Alzheimer's Disease subtypes based on cortical atrophy patterns

Jong-Yun Park; Han Kyu Na; Sungsoo Kim; Hyunwook Kim; Hee Jin Kim; Sang Won Seo; Duk L Na; Cheol E Han; Joon-Kyung Seong; Alzheimer’s Disease Neuroimaging Initiative

doi:10.1038/srep43270

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Robust Identification of Alzheimer's Disease subtypes based on cortical atrophy patterns

Journal article

Open access

Peer reviewed

Robust Identification of Alzheimer's Disease subtypes based on cortical atrophy patterns

Jong-Yun Park, Han Kyu Na, Sungsoo Kim, Hyunwook Kim, Hee Jin Kim, Sang Won Seo, Duk L Na, Cheol E Han, Joon-Kyung Seong and Alzheimer’s Disease Neuroimaging Initiative

Scientific reports, Vol.7(1), pp.43270-43270

03/09/2017

DOI: 10.1038/srep43270

PMCID: PMC5343676

PMID: 28276464

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Abstract

Accumulating evidence suggests that Alzheimer's disease (AD) is heterogenous and can be classified into several subtypes. Here, we propose a robust subtyping method for AD based on cortical atrophy patterns and graph theory. We calculated similarities between subjects in their atrophy patterns throughout the whole brain, and clustered subjects with similar atrophy patterns using the Louvain method for modular organization extraction. We applied our method to AD patients recruited at Samsung Medical Center and externally validated our method by using the AD Neuroimaging Initiative (ADNI) dataset. Our method categorized very mild AD into three clinically distinct subtypes with high reproducibility (>90%); the parietal-predominant (P), medial temporal-predominant (MT), and diffuse (D) atrophy subtype. The P subtype showed the worst clinical presentation throughout the cognitive domains, while the MT and D subtypes exhibited relatively mild presentation. The MT subtype revealed more impaired language and executive function compared to the D subtype.

Magnetic Resonance Imaging

Atrophy - diagnostic imaging

Alzheimer Disease - classification

Humans

Middle Aged

Atrophy - pathology

Cerebral Cortex - pathology

Male

Cerebral Cortex - diagnostic imaging

Alzheimer Disease - pathology

Female

Aged

Alzheimer Disease - diagnostic imaging

Details

Title: Subtitle: Robust Identification of Alzheimer's Disease subtypes based on cortical atrophy patterns
Creators: Jong-Yun Park - School of Biomedical Engineering, Korea University, Seoul, Republic of Korea
Han Kyu Na - Yonsei University College of Medicine, Seoul, Republic of Korea
Sungsoo Kim - Yonsei University College of Medicine, Seoul, Republic of Korea
Hyunwook Kim - Yonsei University College of Medicine, Seoul, Republic of Korea
Hee Jin Kim - Department of Neurology, Samsung Medical Center, Seoul, Republic of Korea
Sang Won Seo - Department of Neurology, Samsung Medical Center, Seoul, Republic of Korea
Duk L Na - Department of Neurology, Samsung Medical Center, Seoul, Republic of Korea
Cheol E Han - Department of Electronics and Information Engineering, Korea University, Sejong, Republic of Korea
Joon-Kyung Seong - School of Biomedical Engineering, Korea University, Seoul, Republic of Korea
Alzheimer’s Disease Neuroimaging Initiative
Contributors: Laura L Boles-Ponto (Contributor) - University of Iowa, Radiology
Resource Type: Journal article
Publication Details: Scientific reports, Vol.7(1), pp.43270-43270
DOI: 10.1038/srep43270
PMID: 28276464
PMCID: PMC5343676
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Publisher: England
Grant note: P50 AG005142 / NIA NIH HHS P30 AG010129 / NIA NIH HHS P41 EB015922 / NIBIB NIH HHS CIHR U01 AG024904 / NIA NIH HHS
Language: English
Date published: 03/09/2017
Academic Unit: Radiology; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984051763002771

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