Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS

Yue Pan; Di Wang; Muhammad F. A. Chaudhary; Wei Shao; Sarah E. Gerard; Oguz C. Durumeric; Surya P. Bhatt; R. Graham Barr; Eric A. Hoffman; Joseph M. Reinhardt; Gary E. Christensen

doi:10.3390/jimaging8110309

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Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS

Journal article

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Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS

Yue Pan, Di Wang, Muhammad F. A. Chaudhary, Wei Shao, Sarah E. Gerard, Oguz C. Durumeric, Surya P. Bhatt, R. Graham Barr, Eric A. Hoffman, Joseph M. Reinhardt, …

Journal of imaging, Vol.8(11), p.309

11/16/2022

DOI: 10.3390/jimaging8110309

PMCID: PMC9693030

PMID: 36422058

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Abstract

Chronic obstructive pulmonary disease (COPD) is an umbrella term used to define a collection of inflammatory lung diseases that cause airflow obstruction and severe damage to the lung parenchyma. This study investigated the robustness of image-registration-based local biomechanical properties of the lung in individuals with COPD as a function of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage. Image registration was used to estimate the pointwise correspondences between the inspiration (total lung capacity) and expiration (residual volume) computed tomography (CT) images of the lung for each subject. In total, three biomechanical measures were computed from the correspondence map: the Jacobian determinant; the anisotropic deformation index (ADI); and the slab-rod index (SRI). CT scans from 245 subjects with varying GOLD stages were analyzed from the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS). Results show monotonic increasing or decreasing trends in the three biomechanical measures as a function of GOLD stage for the entire lung and on a lobe-by-lobe basis. Furthermore, these trends held across all five image registration algorithms. The consistency of the five image registration algorithms on a per individual basis is shown using Bland–Altman plots.

Biomechanics

COPD

image registration

lung

SPIROMICS

Details

Title: Subtitle: Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS
Creators: Yue Pan - University of Iowa
Di Wang - University of Iowa
Muhammad F. A. Chaudhary - University of Iowa
Wei Shao - University of Iowa
Sarah E. Gerard - University of Iowa
Oguz C. Durumeric - University of Iowa
Surya P. Bhatt - University of Iowa
R. Graham Barr - University of Iowa
Eric A. Hoffman - University of Iowa
Joseph M. Reinhardt - University of Iowa
Gary E. Christensen - University of Iowa
Resource Type: Journal article
Publication Details: Journal of imaging, Vol.8(11), p.309
DOI: 10.3390/jimaging8110309
PMID: 36422058
PMCID: PMC9693030
NLM abbreviation: J Imaging
eISSN: 2313-433X
Publisher: MDPI
Grant note: Chiesi Farmaceutici S.p.A. Regeneron Pharmaceuticals, Inc. Theravance Biopharma and Mylan Grifols Therapeutics, Inc. ProterixBio HL142625 / NIH AstraZeneca/MedImmune HHSN268200900013C; HHSN268200900014C; HHSN268200900015C; HHSN268200900016C; HHSN268200900017C; HHSN268200900018C; HHSN268200900019C; HHSN268200900020C; U01 HL137880; U24 HL141762 / NIH/NHLBI Takeda Pharmaceutical Company Novartis Pharmaceuticals Corporation Carver Charitable Trust Bellerophon Therapeutics GlaxoSmithKline Bayer Sunovion Boehringer-Ingelheim Pharmaceuticals, Inc. Sanofi Ikaria, Inc. Nycomed GmbH Forest Research Institute, Inc.
Language: English
Date published: 11/16/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Mathematics; Advanced Pulmonary Physiomic Imaging Laboratory; Holden Comprehensive Cancer Center; Internal Medicine
Record Identifier: 9984318684402771

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