Journal article
Robust automated constellation-based landmark detection in human brain imaging
NeuroImage (Orlando, Fla.), Vol.170, pp.471-481
04/15/2018
DOI: 10.1016/j.neuroimage.2017.04.012
PMCID: PMC5630513
PMID: 28392490
Abstract
A robust fully automated algorithm for identifying an arbitrary number of landmark points in the human brain is described and validated. The proposed method combines statistical shape models with trained brain morphometric measures to estimate midbrain landmark positions reliably and accurately. Gross morphometric constraints provided by automatically identified eye centers and the center of the head mass are shown to provide robust initialization in the presence of large rotations in the initial head orientation. Detection of primary midbrain landmarks are used as the foundation from which extended detection of an arbitrary set of secondary landmarks in different brain regions by applying a linear model estimation and principle component analysis. This estimation model sequentially uses the knowledge of each additional detected landmark as an improved foundation for improved prediction of the next landmark location. The accuracy and robustness of the presented method was evaluated by comparing the automatically generated results to two manual raters on 30 identified landmark points extracted from each of 30 T1-weighted magnetic resonance images. For the landmarks with unambiguous anatomical definitions, the average discrepancy between the algorithm results and each human observer differed by less than 1 mm from the average inter-observer variability when the algorithm was evaluated on imaging data collected from the same site as the model building data. Similar results were obtained when the same model was applied to a set of heterogeneous image volumes from seven different collection sites representing 3 scanner manufacturers. This method is reliable for general application in large-scale multi-site studies that consist of a variety of imaging data with different orientations, spacings, origins, and field strengths.
Details
- Title: Subtitle
- Robust automated constellation-based landmark detection in human brain imaging
- Creators
- Ali Ghayoor - Department of Electrical and Computer Engineering, 1402 Seamans Center for the Engineering Arts and Science, The University of Iowa, Iowa City, IA 52240, USA; Department of Psychiatry, University of Iowa Hospitals & Clinics, Iowa City, IA 52242, USAJatin G Vaidya - Department of Psychiatry, University of Iowa Hospitals & Clinics, Iowa City, IA 52242, USAHans J Johnson - Department of Electrical and Computer Engineering, 1402 Seamans Center for the Engineering Arts and Science, The University of Iowa, Iowa City, IA 52240, USA; Department of Psychiatry, University of Iowa Hospitals & Clinics, Iowa City, IA 52242, USA. Electronic address: hans-johnson@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.170, pp.471-481
- DOI
- 10.1016/j.neuroimage.2017.04.012
- PMID
- 28392490
- PMCID
- PMC5630513
- NLM abbreviation
- Neuroimage
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Publisher
- United States
- Grant note
- U54 EB005149 / NIBIB NIH HHS R01 NS040068 / NINDS NIH HHS U01 NS083223 / NINDS NIH HHS S10 RR023392 / NCRR NIH HHS R01 NS050568 / NINDS NIH HHS R01 EB020062 / NIBIB NIH HHS
- Language
- English
- Date published
- 04/15/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; Iowa Neuroscience Institute; The Iowa Institute for Biomedical Imaging; The Iowa Initiative for Artificial Intelligence; Iowa Informatics Initiative; University College Courses
- Record Identifier
- 9984070777402771
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