Journal article
Robust trend tests for genetic association using matched case-control design
Statistics in medicine, Vol.25(18), pp.3160-3173
09/30/2006
DOI: 10.1002/sim.2278
PMID: 16196079
Abstract
Trend tests for genetic association using a matched case-control design are studied, which allows for a variable number of controls per case. However, the tests depend on the scores based on the underlying genetic model, thus it may result in substantial loss of power when the model is misspecified. Since the mode of inheritance may be unknown for complex diseases, robust trend tests in matched case-control studies are developed. Simulation is conducted to compare the trend tests and the robust trend tests under various genetic models. The results are applied to detect candidate-gene association using an example from a case-control aetiologic study of sarcoidosis.
Details
- Title: Subtitle
- Robust trend tests for genetic association using matched case-control design
- Creators
- Gang Zheng - National Heart Lung and Blood InstituteXin TianA Case Control Etiologic Study of Sarcoidosis (ACCESS) Research GroupLinda S Powers (Contributor) - Internal Medicine
- Resource Type
- Journal article
- Publication Details
- Statistics in medicine, Vol.25(18), pp.3160-3173
- DOI
- 10.1002/sim.2278
- PMID
- 16196079
- ISSN
- 0277-6715
- eISSN
- 1097-0258
- Grant note
- N01-HR-56070 / NHLBI NIH HHS N01-HR-56072 / NHLBI NIH HHS N01-HR-56068 / NHLBI NIH HHS N01-HR-56074 / NHLBI NIH HHS N01-HR-56069 / NHLBI NIH HHS N01-HR-56066 / NHLBI NIH HHS N01-HR-56071 / NHLBI NIH HHS N01-HR-56073 / NHLBI NIH HHS N01-HR-56075 / NHLBI NIH HHS N01-HR-56067 / NHLBI NIH HHS N01-HR-56065 / NHLBI NIH HHS
- Language
- English
- Date published
- 09/30/2006
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984622755002771
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