Rodent models of diabetic cardiomyopathy

Heiko Bugger; E Dale Abel

doi:10.1242/dmm.001941

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Rodent models of diabetic cardiomyopathy

Journal article

Open access

Peer reviewed

Rodent models of diabetic cardiomyopathy

Heiko Bugger and E Dale Abel

Disease models & mechanisms, Vol.2(9-10), pp.454-466

09/2009

DOI: 10.1242/dmm.001941

PMID: 19726805

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https://doi.org/10.1242/dmm.001941View

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Abstract

Diabetic cardiomyopathy increases the risk of heart failure in individuals with diabetes, independently of co-existing coronary artery disease and hypertension. The underlying mechanisms for this cardiac complication are incompletely understood. Research on rodent models of type 1 and type 2 diabetes, and the use of genetic engineering techniques in mice, have greatly advanced our understanding of the molecular mechanisms responsible for human diabetic cardiomyopathy. The adaptation of experimental techniques for the investigation of cardiac physiology in mice now allows comprehensive characterization of these models. The focus of the present review will be to discuss selected rodent models that have proven to be useful in studying the underlying mechanisms of human diabetic cardiomyopathy, and to provide an overview of the characteristics of these models for the growing number of investigators who seek to understand the pathology of diabetes-related heart disease.

Animals

Genetic Engineering

Humans

Rodentia - genetics

Cardiomyopathies - complications

Diabetes Complications - complications

Disease Models, Animal

Details

Title: Subtitle: Rodent models of diabetic cardiomyopathy
Creators: Heiko Bugger - Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
E Dale Abel
Resource Type: Journal article
Publication Details: Disease models & mechanisms, Vol.2(9-10), pp.454-466
DOI: 10.1242/dmm.001941
PMID: 19726805
NLM abbreviation: Dis Model Mech
ISSN: 1754-8403
eISSN: 1754-8411
Publisher: England
Grant note: R01 HL070070 / NHLBI NIH HHS R01 DK092065 / NIDDK NIH HHS U01 HL087947 / NHLBI NIH HHS
Language: English
Date published: 09/2009
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984025273202771

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