Journal article
Rodents as genetic models of obesity
Drug discovery today. Disease models, Vol.2(3), pp.165-175
2005
DOI: 10.1016/j.ddmod.2005.08.005
Abstract
There is a high demand for effective pharmacotherapy against obesity as its prevalence increases worldwide. Rodent models have advanced our knowledge of energy homeostasis and are widely used for obesity research. This review describes rodent models of obesity involving spontaneous mutations, knockout or overexpression of genes involved in energy balance and dietary intervention in polygenic rodents. Understanding of the characteristics of these models will facilitate development of therapies for obesity and related diseases.
Alexandre Steiner – Systemic Inflammation Laboratory, St Joseph's Hospital and Medical Center, Phoenix, AR, USA
Details
- Title: Subtitle
- Rodents as genetic models of obesity
- Creators
- Yumi Imai - University of PennsylvaniaRexford S. Ahima - University of Pennsylvania
- Resource Type
- Journal article
- Publication Details
- Drug discovery today. Disease models, Vol.2(3), pp.165-175
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.ddmod.2005.08.005
- ISSN
- 1740-6757
- eISSN
- 1740-6757
- Language
- English
- Date published
- 2005
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359776102771
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