Journal article
Role for CCR7 Ligands in the Emigration of Newly Generated T Lymphocytes from the Neonatal Thymus
Immunity (Cambridge, Mass.), Vol.16(2), pp.205-218
2002
DOI: 10.1016/S1074-7613(02)00267-4
PMID: 11869682
Abstract
Most T lymphocytes are generated within the thymus. It is unclear, however, how newly generated T cells relocate out of the thymus to the circulation. The present study shows that a CC chemokine CCL19 attracts mature T cells out of the fetal thymus organ culture. Another CC chemokine CCL21, which shares CCR7 with CCL19 but has a unique C-terminal extension containing positively charged amino acids, failed to show involvement in thymic emigration. Neonatal appearance of circulating T cells was defective in CCL19-neutralized mice as well as in CCR7-deficient mice but not in CCL21-neutralized mice. In the thymus, CCL19 is predominantly localized in the medulla including endothelial venules. These results indicate a CCL19- and CCR7-dependent pathway of thymic emigration, which represents a major pathway of neonatal T cell export.
Details
- Title: Subtitle
- Role for CCR7 Ligands in the Emigration of Newly Generated T Lymphocytes from the Neonatal Thymus
- Creators
- Tomoo Ueno - Tokushima UniversityKyoko Hara - Tokushima UniversityMelissa Swope Willis - Harvard Medical SchoolMark A. Malin - Monash UniversityUta E. Höpken - Max Delbrück CenterDaniel H.D. Gray - Monash UniversityKouji Matsushima - The University of TokyoMartin Lipp - Max Delbrück CenterTimothy A. Springer - Harvard Medical SchoolRichard L. Boyd - Monash UniversityOsamu Yoshie - Kindai UniversityYousuke Takahama - Tokushima University
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.16(2), pp.205-218
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S1074-7613(02)00267-4
- PMID
- 11869682
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 2002
- Academic Unit
- Dermatology
- Record Identifier
- 9984296210802771
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