Journal article
Role for Nox1 NADPH oxidase in atherosclerosis
Atherosclerosis, Vol.216(2), pp.321-326
06/01/2011
DOI: 10.1016/j.atherosclerosis.2011.02.028
PMCID: PMC3110523
PMID: 21411092
Abstract
Objective: Examine the contribution of Nox1 NADPH oxidase to atherogenesis.
Methods and results: Male apolipoprotein E deficient mice (ApoE(-/-)) and male mice deficient in both apolipoprotein E and Nox1 (ApoE(-/-) Nox1(-/y)) received an atherogenic diet for 18 weeks. Mean blood pressures, body weights, and serum cholesterol levels were similar between the two groups of mice. Deficiency of Nox1 decreased superoxide levels and reduced lesion area in the aortic arch from 43% (ApoE(-/-)) to 28% (ApoE(-/-)Nox1(-/y)). The reduction in lesion size at the level of the aortic valve in ApoE(-/-)/Nox1(-/y) was accompanied by a decrease in macrophage infiltration as compared to ApoE(-/-) mice. Carotid artery ligation in ApoE(-/-) mice induced accelerated intimal hyperplasia with decreased cellular proliferation and increased collagen content in the neointima of vessels deficient in Nox1.
Conclusions: Nox1-derived ROS modify lesion composition and contribute to lesion size in a murine model of atherosclerosis. Published by Elsevier Ireland Ltd.
Details
- Title: Subtitle
- Role for Nox1 NADPH oxidase in atherosclerosis
- Creators
- Andrea L. Sheehan - University of IowaSamuel Carrell - University of IowaBryon Johnson - University of IowaBojana Stanic - University of IowaBotond Banfi - University of IowaFrancis J. Miller - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Atherosclerosis, Vol.216(2), pp.321-326
- Publisher
- Elsevier
- DOI
- 10.1016/j.atherosclerosis.2011.02.028
- PMID
- 21411092
- PMCID
- PMC3110523
- ISSN
- 0021-9150
- eISSN
- 1879-1484
- Number of pages
- 6
- Grant note
- HL081750 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Office of Research and Development, Department of Veterans Affairs; US Department of Veterans Affairs P30DK054759 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) P30 DK 54759 / NIH/NIDDK; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01HL081750 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 06/01/2011
- Academic Unit
- Anatomy and Cell Biology; Otolaryngology; Internal Medicine
- Record Identifier
- 9984284348202771
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