Journal article
Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells: Neurodegeneration and Neuroprotection
Cells (Basel, Switzerland), Vol.12(11), 1539
01/01/2023
DOI: 10.3390/cells12111539
PMCID: PMC10252895
PMID: 37296658
Abstract
A-Kinase anchoring protein 1 (AKAP1) is a multifunctional mitochondrial scaffold protein that regulates mitochondrial dynamics, bioenergetics, and calcium homeostasis by anchoring several proteins, including protein kinase A, to the outer mitochondrial membrane. Glaucoma is a complex, multifactorial disease characterized by a slow and progressive degeneration of the optic nerve and retinal ganglion cells (RGCs), ultimately resulting in vision loss. Impairment of the mitochondrial network and function is linked to glaucomatous neurodegeneration. Loss of AKAP1 induces dynamin-related protein 1 dephosphorylation-mediated mitochondrial fragmentation and loss of RGCs. Elevated intraocular pressure triggers a significant reduction in AKAP1 protein expression in the glaucomatous retina. Amplification of AKAP1 expression protects RGCs from oxidative stress. Hence, modulation of AKAP1 could be considered a potential therapeutic target for neuroprotective intervention in glaucoma and other mitochondria-associated optic neuropathies. This review covers the current research on the role of AKAP1 in the maintenance of mitochondrial dynamics, bioenergetics, and mitophagy in RGCs and provides a scientific basis to identify and develop new therapeutic strategies that could protect RGCs and their axons in glaucoma.
Details
- Title: Subtitle
- Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells: Neurodegeneration and Neuroprotection
- Creators
- Tonking Bastola - University of California San DiegoGuy Perkins - University of California San DiegoKim Keun-YoungSeunghwan ChoiKwon Jin-WooZiyao Shen - University of California San DiegoStefan Strack - University of IowaWon-Kyu Ju - University of California San Diego
- Resource Type
- Journal article
- Publication Details
- Cells (Basel, Switzerland), Vol.12(11), 1539
- DOI
- 10.3390/cells12111539
- PMID
- 37296658
- PMCID
- PMC10252895
- NLM abbreviation
- Cells
- eISSN
- 2073-4409
- Publisher
- MDPI AG
- Grant note
- name: National Institutes of Health, award: EY031697
- Language
- English
- Date published
- 01/01/2023
- Academic Unit
- Pathology; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
- Record Identifier
- 9984426746702771
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