Journal article
Role of ATP-Sensitive Potassium Channels in Coronary Microvascular Autoregulatory Responses
Circulation research, Vol.69(4), pp.1146-1151
10/1991
DOI: 10.1161/01.RES.69.4.1146
PMID: 1934341
Abstract
The purpose of the present study was to test the hypothesis that ATP-sensitive potassium channels mediate autoregulatory vasodilatation of coronary arterioles in vivo. Experiments were performed in 23 open-chest anesthetized dogs. Coronary arterial microvascular diameters were directly measured with fluorescence microangiography using an intravital microscope and stroboscopic epi-illumination synchronized to the cardiac cycle. A mild coronary stenosis (perfusion pres-sure=60 mm Hg), a critical coronary stenosis (perfusion pressure=40 mm Hg), and complete coronary artery occlusion were produced with an occluder around the left anterior descending coronary artery in the presence or absence of glibenclamide (10- M, topically), which inhibits ATP-sensitive potassium channels, or of vehicle. During topical application of vehicle (0.01% dimethyl sulfoxide), there was dilatation of small (<100 μm diameter) arterioles during reductions in perfusion pressure (percent change in diameter. 6.7±1.5%, 11.7±3.5%, and 10.4±5.1% during mild stenosis, critical stenosis, and complete occlusion, respectively). In the presence of glibenclamide, arteriolar dilatations during coronary stenoses and occlusions were abolished. Glibenclamide did not affect responses of arterioles >100 μm. Glibenclamide did not alter microvascular responses to nitroprusside. These data suggest that ATP-sensitive potassium channels play an important role in determining the coronary microvascular response to reductions in perfusion pressure. (Circulation Research 1991;69:1146–1151)
Details
- Title: Subtitle
- Role of ATP-Sensitive Potassium Channels in Coronary Microvascular Autoregulatory Responses
- Creators
- Tatsuya Komaru - Department of Internal Medicine and The Cardiovascular Center, College of Medicine, University of Iowa, Iowa City, IowaKathryn LampingCharles EasthamKevin Dellsperger
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.69(4), pp.1146-1151
- DOI
- 10.1161/01.RES.69.4.1146
- PMID
- 1934341
- NLM abbreviation
- Circ Res
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Publisher
- American Heart Association, Inc
- Language
- English
- Date published
- 10/1991
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984094754402771
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