Journal article
Role of Airway Epithelial Ion Transport in Pulmonary Mucociliary Clearance
Allergy and asthma proceedings, Vol.5(3), pp.212-217
07/01/1984
DOI: 10.2500/108854184779109260
Abstract
Mucociliary clearance is an important pulmonary defense mechanism that serves to remove inhaled particulate material from the lung. Effective function of the mucociliary clearance apparatus is dependent upon ciliary activity, the viscoelastic mucus, and ion transport by the airway epithelia.
Recent studies of the airway epithelium show that it is capable of either active Na absorption or Cl secretion and that the direction and magnitude of salt and water transport is under neurohumoral control. Finally, there is increasing evidence that abnormalities of epithelial ion transport
may be important in the pathogenesis of a variety of pulmonary diseases. Further investigation of both the normal and abnormal physiology of epithelial ion transport should increase our understanding of the mechanisms involved and may lead to the development of more rational therapeutic modalities.
Details
- Title: Subtitle
- Role of Airway Epithelial Ion Transport in Pulmonary Mucociliary Clearance
- Creators
- Michael Welsh - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Allergy and asthma proceedings, Vol.5(3), pp.212-217
- Publisher
- OceanSide Publications, Inc
- DOI
- 10.2500/108854184779109260
- ISSN
- 1088-5412
- eISSN
- 1539-6304
- Language
- English
- Date published
- 07/01/1984
- Academic Unit
- Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Neurology; Internal Medicine
- Record Identifier
- 9984259505502771
Metrics
2 Record Views