Journal article
Role of Aldosterone on Renal Sodium and Potassium Excretion during Fetal Life and Newborn Period
Developmental pharmacology and therapeutics, Vol.1(4), pp.201-216
01/01/1980
DOI: 10.1159/000455538
PMID: 7002509
Abstract
The renal response to endogenous aldosterone production at different times
during gestation and immediately after birth, as well as factors controlling aldosterone
secretion during fetal life have been studied in 34 lamb fetuses (106-142 days of gestation,
term 145 days) and in 6 newborn lambs (3-8 days postnatal age). lt was demonstrated that
the increase in fetal plasma aldosterone concentration correlated with the increase in fetal
plasma renin activity (PRA) (r = 0.67, p < 0.001). Moreover, it was found that the slope of
the regression line between plasma aldosterone and PRA during fetal life was significantly
steeper (p < 0.05) than after birth. Significant correlation coefficients were found between
the fetal urinary to plasma ratios (U/P) of sodium over potassium [(U/P)Na+/(U/P)K+J and
either fetal plasma aldosterone (r = 0.53, p < 0.005) or fetal age (r = - 0.5 2, p < 0.005 ).
Moreover, in 7 out of 9 fetuses over 125 days, frank secretion of potassium by the fetal
tubular cells was demonstrated; such a secretion was present in only 1 of the 15 fetuses
between 101 and 125 days of gestation. Finally , it was demonstrated that the increase in
mean arterial blood pressure during fetal life and after birth is not a major Iactor in thc
increase in fetal glomerular filtration rate during gestation or in the adaptation of glomerular
filtration rate to extrauterine life.
Details
- Title: Subtitle
- Role of Aldosterone on Renal Sodium and Potassium Excretion during Fetal Life and Newborn Period
- Creators
- Jean E. Robillard - University of IowaEric Ramberg - University of IowaChristine Sessions - University of IowaBridget Consamus - University of IowaDianna Van Orden - University of IowaDouglas Weismann - University of IowaFred G. Smith Jr
- Resource Type
- Journal article
- Publication Details
- Developmental pharmacology and therapeutics, Vol.1(4), pp.201-216
- DOI
- 10.1159/000455538
- PMID
- 7002509
- ISSN
- 0379-8305
- eISSN
- 2504-2505
- Number of pages
- 16
- Language
- English
- Date published
- 01/01/1980
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984774213202771
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