Journal article
Role of Anteroventral Third Ventricle and Vasopressin in Renal Response to Stress in Borderline Hypertensive Rats
Hypertension (Dallas, Tex. 1979), Vol.17(6, Part 1), pp.755-762
06/1991
DOI: 10.1161/01.HYP.17.6.755
PMID: 2045136
Abstract
The borderline hypertensive rat is the first filial offspring of the spontaneously hypertensive rat and the Wistar-Kyoto rat In response to acute environmental stress (air jet), the borderline hypertensive rat exhibits a diuretic response, whereas the parental strains exhibit an antidiuretic response (spontaneously hypertensive rat) or no change in urine flow rate (Wistar-Kyoto rat). This study sought to investigate the role of the periventricular tissue surrounding the anteroventral third ventricle and vasopressin release in the diuretic response of the borderline hypertensive rat to acute environmental stress. Sixteen-week-old borderline hypertensive rats who had consumed a 1% NaCl diet for 10-12 weeks were given either electrolytic lesions of the anteroventral portion of the third ventricle or sham lesions. When exposed to acute environmental stress 4 weeks later, the increase in volume of dilute urine seen in the sham-lesion rats was not observed in the lesion rats. Plasma vasopressin concentration was decreased by acute environmental stress in the sham-lesion rats (15.2±4.0 to 10.9±1.7 pg/ml, p<0.05) but was unchanged in the lesion rats (12J±2.0 to 13.4±4.0 pg/ml). In a separate group of intact borderline hypertensive rats, a constant intravenous infusion of vasopressin prevented the diuretic response to acute environmental stress. The results suggest that acute environmental stress produces a diuresis in the borderline hypertensive rats via a decrease in plasma vasopressin concentration that is dependent on the integrity of the periventricular tissue of the anteroventral portion of the third ventricle.
Details
- Title: Subtitle
- Role of Anteroventral Third Ventricle and Vasopressin in Renal Response to Stress in Borderline Hypertensive Rats
- Creators
- Daniel Hatton - Department of Medical Psychology (D.C.H.), Oregon Health Sciences University, Portland, Ore., and the Departments of Internal Medicine (S.YJ., G.F.D.), Psychology (A.KJ.), and Pharmacology (A.KJ.), University of Iowa and Veterans Administration Medical Center, Iowa City, IowaSusan JonesAlan Kim JohnsonGerald DiBona
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.17(6, Part 1), pp.755-762
- DOI
- 10.1161/01.HYP.17.6.755
- PMID
- 2045136
- NLM abbreviation
- Hypertension
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Publisher
- American Heart Association, Inc
- Language
- English
- Date published
- 06/1991
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984213265102771
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