Role of CaMKII in Ang-II-dependent small artery remodeling

Anand M Prasad; Pimonrat Ketsawatsomkron; Daniel W Nuno; Olha M Koval; Megan E Dibbern; Ashlee N Venema; Curt D Sigmund; Kathryn G Lamping; Isabella M Grumbach

doi:10.1016/j.vph.2016.09.007

Back

Role of CaMKII in Ang-II-dependent small artery remodeling

Journal article

Open access

Peer reviewed

Role of CaMKII in Ang-II-dependent small artery remodeling

Anand M Prasad, Pimonrat Ketsawatsomkron, Daniel W Nuno, Olha M Koval, Megan E Dibbern, Ashlee N Venema, Curt D Sigmund, Kathryn G Lamping and Isabella M Grumbach

Vascular pharmacology, Vol.87, pp.172-179

12/2016

DOI: 10.1016/j.vph.2016.09.007

PMCID: PMC5164857

PMID: 27658984

Files and links (1)

url

https://doi.org/10.1016/j.vph.2016.09.007View

Published (Version of record) Open Access

Abstract

Angiotensin-II (Ang-II) is a well-established mediator of vascular remodeling. The multifunctional calcium-calmodulin-dependent kinase II (CaMKII) is activated by Ang-II and regulates Erk1/2 and Akt-dependent signaling in cultured smooth muscle cells in vitro. Its role in Ang-II-dependent vascular remodeling in vivo is far less defined. Using a model of transgenic CaMKII inhibition selectively in smooth muscle cells, we found that CaMKII inhibition exaggerated remodeling after chronic Ang-II treatment and agonist-dependent vasoconstriction in second-order mesenteric arteries. These findings were associated with increased mRNA and protein expression of smooth muscle structural proteins. As a potential mechanism, CaMKII reduced serum response factor-dependent transcriptional activity. In summary, our findings identify CaMKII as an important regulator of smooth muscle function in Ang-II hypertension in vivo. [Display omitted]

Smooth muscle

CaMKII

Ang-II

Remodeling

Details

Title: Subtitle: Role of CaMKII in Ang-II-dependent small artery remodeling
Creators: Anand M Prasad - Department of Medicine, Carver College, University of Iowa, Iowa City, United States
Pimonrat Ketsawatsomkron - Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, United States
Daniel W Nuno - Department of Medicine, Carver College, University of Iowa, Iowa City, United States
Olha M Koval - Department of Medicine, Carver College, University of Iowa, Iowa City, United States
Megan E Dibbern - Department of Medicine, Carver College, University of Iowa, Iowa City, United States
Ashlee N Venema - Department of Medicine, Carver College, University of Iowa, Iowa City, United States
Curt D Sigmund - Department of Medicine, Carver College, University of Iowa, Iowa City, United States
Kathryn G Lamping - Department of Medicine, Carver College, University of Iowa, Iowa City, United States
Isabella M Grumbach - Department of Medicine, Carver College, University of Iowa, Iowa City, United States
Resource Type: Journal article
Publication Details: Vascular pharmacology, Vol.87, pp.172-179
DOI: 10.1016/j.vph.2016.09.007
PMID: 27658984
PMCID: PMC5164857
NLM abbreviation: Vascul Pharmacol
ISSN: 1537-1891
eISSN: 1879-3649
Publisher: Elsevier Inc
Language: English
Date published: 12/2016
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Radiation Oncology; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984094364702771

Metrics

14 Record Views

6 Times Cited - Web of Science