Role of FABP5 in T Cell Lipid Metabolism and Function in the Tumor Microenvironment

Rong Jin; Jiaqing Hao; Jianyu Yu; Pingzhang Wang; Edward R. Sauter; Bing Li

doi:10.3390/cancers15030657

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Role of FABP5 in T Cell Lipid Metabolism and Function in the Tumor Microenvironment

Journal article

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Role of FABP5 in T Cell Lipid Metabolism and Function in the Tumor Microenvironment

Rong Jin, Jiaqing Hao, Jianyu Yu, Pingzhang Wang, Edward R. Sauter and Bing Li

Cancers, Vol.15(3), 657

01/20/2023

DOI: 10.3390/cancers15030657

PMCID: PMC9913835

PMID: 36765614

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https://doi.org/10.3390/cancers15030657View

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Abstract

To evade immune surveillance, tumors develop a hostile microenvironment that inhibits anti-tumor immunity. Recent immunotherapy breakthroughs that target the reinvigoration of tumor-infiltrating T lymphocytes (TIL) have led to unprecedented success in treating some cancers that are resistant to conventional therapy, suggesting that T cells play a pivotal role in anti-tumor immunity. In the hostile tumor microenvironment (TME), activated T cells are known to mainly rely on aerobic glycolysis to facilitate their proliferation and anti-tumor function. However, TILs usually exhibit an exhausted phenotype and impaired anti-tumor activity due to the limited availability of key nutrients (e.g., glucose) in the TME. Given that different T cell subsets have unique metabolic pathways which determine their effector function, this review introduces our current understanding of T cell development, activation signals and metabolic pathways. Moreover, emerging evidence suggests that fatty acid binding protein 5 (FABP5) expression in T cells regulates T cell lipid metabolism and function. We highlight how FABP5 regulates fatty acid uptake and oxidation, thus shaping the survival and function of different T cell subsets in the TME.

Details

Title: Subtitle: Role of FABP5 in T Cell Lipid Metabolism and Function in the Tumor Microenvironment
Creators: Rong Jin - University of Louisville
Jiaqing Hao - University of Iowa
Jianyu Yu - University of Iowa
Pingzhang Wang - Peking University
Edward R. Sauter - Division of Cancer Prevention, National Institutes of Health/National Cancer Institute, Bethesda, MD 20892, USA
Bing Li - University of Louisville
Resource Type: Journal article
Publication Details: Cancers, Vol.15(3), 657
DOI: 10.3390/cancers15030657
PMID: 36765614
PMCID: PMC9913835
NLM abbreviation: Cancers (Basel)
ISSN: 2072-6694
eISSN: 2072-6694
Language: English
Date published: 01/20/2023
Academic Unit: Pathology
Record Identifier: 9984363420302771

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