Journal article
Role of Hypoxia-Inducible Factors in Acute Kidney Injury
Nephron. Clinical practice, Vol.127(1-4), pp.70-74
01/01/2014
DOI: 10.1159/000363669
PMID: 25343825
Abstract
Oxygen is vital to mammalian survival. Oxygen deprivation, defined as hypoxia, elicits adaptive responses in cells and tissues, a process regulated by proteins known as hypoxia- inducible factors (HIF). Animal studies have provided compelling data to demonstrate a pivotal role for the HIF pathway in the pathogenesis of acute kidney injury (AKI) that have led to initial human clinical trials examining this pathway in ischemia-reperfusion injury in various organ systems, including the kidney. HIF are master regulators and mediate adaptive responses to low oxygen in tissues and cells. This review will summarize recent key advances in the field highlighting preclinical and clinical studies relevant to the HIF pathway in the pathophysiology of AKI. (C) 2014 S. Karger AG, Basel
Details
- Title: Subtitle
- Role of Hypoxia-Inducible Factors in Acute Kidney Injury
- Creators
- Kelly K. Andringa - Pediatric Nephrology of AlabamaAnupam Agarwal - University of Alabama at Birmingham
- Resource Type
- Journal article
- Publication Details
- Nephron. Clinical practice, Vol.127(1-4), pp.70-74
- Publisher
- Karger
- DOI
- 10.1159/000363669
- PMID
- 25343825
- ISSN
- 1660-2110
- eISSN
- 1660-2110
- Number of pages
- 5
- Grant note
- P30 DK079337 / O'Brien Center P30DK079337 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01 DK059600 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 01/01/2014
- Academic Unit
- Orthopedics and Rehabilitation
- Record Identifier
- 9984548857102771
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