Journal article
Role of Lymphovascular Invasion in Oral Cavity Squamous Cell Carcinoma Regional Metastasis and Prognosis
Annals of otology, rhinology & laryngology, Vol.133(3), pp.300-306
03/2024
DOI: 10.1177/00034894231211116
PMCID: PMC11578272
PMID: 37927046
Abstract
Objective: The overall 5-year survival for oral squamous cell carcinoma (OSCC) has not changed in the last 20 years despite advances in treatment. Lymphovascular invasion (LVI) has been shown to be a negative prognostic factor in other cancers, however its role in the prognosis of OSCC remains unclear. This study aims to determine if LVI is a predictor of cervical lymph node metastasis and/or recurrence in OSCC. Methods: We conducted a retrospective cohort review of patients from our institutional cancer registry who were treated for OSCC between 2004 and 2018. Patient demographics, surgical pathology results, and clinical outcome data were collected. A multivariable logistic regression analysis was performed to determine if LVI was an independent predictor of cervical lymph node metastasis and/or recurrence. Results: 442 patients were included, 32.8% were female and median age at time of diagnosis was 61.2 years. LVI was present in 32.8% of patients. When controlled for age, sex, t-classification, perineural invasion, depth of invasion (DOI), and margin status, LVI was a significant predictor of the presence of cervical node metastasis (OR: 3.42, CI: 2.17-5.39, P < .001). There was no significant association found between LVI and local recurrence (OR: 1.03, CI: 0.57-1.84, P = .92), regional recurrence (OR: 1.10, CI: 0.57-2.11, P = .78), or distant recurrence (OR: 1.59, CI: 0.87-2.94, P = .13). Conclusion: The results of this study suggest that LVI is a significant predictor of the presence of cervical lymph node metastasis at presentation independent of other known prognostic factors. LVI, however, was not found to be a significant independent predictor of locoregional or distant recurrence. Level of Evidence: Level III
Details
- Title: Subtitle
- Role of Lymphovascular Invasion in Oral Cavity Squamous Cell Carcinoma Regional Metastasis and Prognosis
- Creators
- Abigail E. Moore - University of IowaSameer A. Alvi - University of Iowa Hospitals and ClinicsOsama Tarabichi - University of Iowa Hospitals and ClinicsVivian L. Zhu - University of IowaMarisa R. Buchakjian - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Annals of otology, rhinology & laryngology, Vol.133(3), pp.300-306
- DOI
- 10.1177/00034894231211116
- PMID
- 37927046
- PMCID
- PMC11578272
- NLM abbreviation
- Ann Otol Rhinol Laryngol
- ISSN
- 0003-4894
- eISSN
- 1943-572X
- Language
- English
- Electronic publication date
- 11/05/2023
- Date published
- 03/2024
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984507025202771
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