Role of Polymorphic Variants as Genetic Modulators of Infection in Neonatal Sepsis

Asmaa ABU-MAZIAD; Kendra SCHAA; Edward F BELL; John M DAGLE; Margaret COOPER; Mary L MARAZITA; Jeffrey C MURRAY

doi:10.1203/PDR.0b013e3181e6a068

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Role of Polymorphic Variants as Genetic Modulators of Infection in Neonatal Sepsis

Journal article

Open access

Peer reviewed

Role of Polymorphic Variants as Genetic Modulators of Infection in Neonatal Sepsis

Asmaa ABU-MAZIAD, Kendra SCHAA, Edward F BELL, John M DAGLE, Margaret COOPER, Mary L MARAZITA and Jeffrey C MURRAY

Pediatric research, Vol.68(4), pp.323-329

2010

DOI: 10.1203/PDR.0b013e3181e6a068

PMCID: PMC2940937

PMID: 20463618

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Abstract

This study is a retrospective, case control study involving 535 preterm infants examining the roles of sequence polymorphisms in genes that mediate host immune responses to bacterial infection in newborn infants. A total of 49 single nucleotide polymorphisms (SNPs) in 19 candidate genes including inflammatory cytokines (IL6, IL10, IL1B, and TNF), cytokine receptors (IL1RN), toll-like receptors (TLR2, TLR4, and TLR5), and cell surface receptors (CD14) were genotyped. Subjects were stratified into three groups (sepsis, suspected sepsis, and control). The data were analyzed using a family-based transmission disequilibrium test. We found that birth weight, gestational age, duration of rupture of membranes, and presence of clinical chorioamnionitis were strongly associated with sepsis. Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. Allelic variants in PLA2G2A and TLR2 were associated with Gram-positive infections, whereas IL10 was associated with Gram-negative infections (p < 0.05). We conclude allelic variations in PLA2G2A, TLR2, TLR5, and IL10 may moderate the predisposition to sepsis in preterm infants.

Infectious Diseases

General aspects

Bacterial diseases

Human bacterial diseases

Biological and medical sciences

Medical sciences

Bacterial sepsis

Details

Title: Subtitle: Role of Polymorphic Variants as Genetic Modulators of Infection in Neonatal Sepsis
Creators: Asmaa ABU-MAZIAD - Department of Pediatrics University of Iowa, Children's Hospital, Iowa City, Iowa 52242, United States
Kendra SCHAA - Department of Pediatrics University of Iowa, Children's Hospital, Iowa City, Iowa 52242, United States
Edward F BELL - Department of Pediatrics University of Iowa, Children's Hospital, Iowa City, Iowa 52242, United States
John M DAGLE - Department of Pediatrics University of Iowa, Children's Hospital, Iowa City, Iowa 52242, United States
Margaret COOPER - Center for Craniofacial and Dental Genetics , University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States
Mary L MARAZITA - Center for Craniofacial and Dental Genetics , University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States
Jeffrey C MURRAY - Department of Pediatrics University of Iowa, Children's Hospital, Iowa City, Iowa 52242, United States
Resource Type: Journal article
Publication Details: Pediatric research, Vol.68(4), pp.323-329
DOI: 10.1203/PDR.0b013e3181e6a068
PMID: 20463618
PMCID: PMC2940937
NLM abbreviation: Pediatr Res
ISSN: 0031-3998
eISSN: 1530-0447
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
Language: English
Date published: 2010
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Biochemistry and Molecular Biology; Dental Research; Neonatology
Record Identifier: 9984024512502771

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