Journal article
Role of Potassium Channels in Cerebral Blood Vessels
Stroke (1970), Vol.26(9), pp.1713-1723
09/1995
DOI: 10.1161/01.STR.26.9.1713
PMID: 7660420
Abstract
Background: Hyperpolarization of vascular muscle in response to activation of potassium channels is a major mechanism of vasodilatation. In cerebral blood vessels, four different potassium channels have been described: ATP-sensitive potassium channels, calcium-activated potassium channels, delayed rectifier potassium channels, and inward rectifier potassium channels.
Summary of review: Activation of ATP-sensitive and calcium activated potassium channels appears to play a major role in relaxation of cerebral arteries and arterioles in response to diverse stimuli, including receptor-mediated agonists, intracellular second messengers, and hypoxia. Both calcium-activated and delayed rectifier potassium channels may contribute to a negative feedback system that regulates tone in large cerebral arteries. The influence of ATP-sensitive and calcium-activated potassium channels is altered in disease states such as hypertension, diabetes, and atherosclerosis.
Conclusions: Activation of potassium channels is a major mechanism of cerebral vasodilatation. Alteration of activity of potassium channels and impairment of vasodilatation may contribute to the development or maintenance of cerebral ischemia or vasospasm.
Details
- Title: Subtitle
- Role of Potassium Channels in Cerebral Blood Vessels
- Creators
- Takanari Kitazono - From the Departments of Internal Medicine and Pharmacology, Cardiovascular Center and Center on Aging, University of Iowa College of Medicine, and Veterans Administration Medical Center, Iowa CityFrank M Faraci - From the Departments of Internal Medicine and Pharmacology, Cardiovascular Center and Center on Aging, University of Iowa College of Medicine, and Veterans Administration Medical Center, Iowa CityHisao Taguchi - From the Departments of Internal Medicine and Pharmacology, Cardiovascular Center and Center on Aging, University of Iowa College of Medicine, and Veterans Administration Medical Center, Iowa CityDonald D Heistad - From the Departments of Internal Medicine and Pharmacology, Cardiovascular Center and Center on Aging, University of Iowa College of Medicine, and Veterans Administration Medical Center, Iowa City
- Resource Type
- Journal article
- Publication Details
- Stroke (1970), Vol.26(9), pp.1713-1723
- DOI
- 10.1161/01.STR.26.9.1713
- PMID
- 7660420
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Language
- English
- Date published
- 09/1995
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040335202771
Metrics
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