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Role of T-Type Ca2+ Channels in Painful Diabetic Neuropathy
Journal article   Peer reviewed

Role of T-Type Ca2+ Channels in Painful Diabetic Neuropathy

P. V Belan, Y. M Usachev, D. E Duzhyy, S. Y Ivanova, A. N Tarasenko and N. V Voitenko
Neurophysiology (New York), Vol.51(6), pp.455-461
11/2019
DOI: 10.1007/s11062-020-09842-9

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Abstract

Numerous investigations implicate pronounced changes in the functioning of T-type Ca2+ channels localized on the somata of primary nociceptor units in the development and maintenance of painful diabetic neuropathy. This review highlights the role of T-type Ca2+ channels of nociceptive afferents in the processing of pain signals under diabetic conditions, as well as suggests a promising therapeutic strategy to treat painful diabetic neuropathy.

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