Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae

A Rambukkana; H Yamada; G Zanazzi; T Mathus; J L Salzer; P D Yurchenco; K P Campbell; V A Fischetti

doi:10.1126/science.282.5396.2076

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Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae

Journal article

Peer reviewed

Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae

A Rambukkana, H Yamada, G Zanazzi, T Mathus, J L Salzer, P D Yurchenco, K P Campbell and V A Fischetti

Science (American Association for the Advancement of Science), Vol.282(5396), pp.2076-2079

12/11/1998

DOI: 10.1126/science.282.5396.2076

PMID: 9851927

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Abstract

alpha-Dystroglycan (alpha-DG) is a component of the dystroglycan complex, which is involved in early development and morphogenesis and in the pathogenesis of muscular dystrophies. Here, alpha-DG was shown to serve as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy. Mycobacterium leprae specifically bound to alpha-DG only in the presence of the G domain of the alpha2 chain of laminin-2. Native alpha-DG competitively inhibited the laminin-2-mediated M. leprae binding to primary Schwann cells. Thus, M. leprae may use linkage between the extracellular matrix and cytoskeleton through laminin-2 and alpha-DG for its interaction with Schwann cells.

Receptors, Laminin - metabolism

Peripheral Nerves - chemistry

Membrane Glycoproteins - metabolism

Humans

Dystroglycans

Recombinant Fusion Proteins - metabolism

Calcium - physiology

Edetic Acid - pharmacology

Cytoskeletal Proteins - pharmacology

Cytoskeletal Proteins - metabolism

Binding Sites

Recombinant Proteins - metabolism

Membrane Glycoproteins - pharmacology

Cells, Cultured

Mycobacterium leprae - metabolism

Rats

Recombinant Proteins - chemistry

Glycosylation

Schwann Cells - metabolism

Bacterial Adhesion

Animals

Laminin - chemistry

Laminin - metabolism

Schwann Cells - microbiology

Cell Line, Transformed

Details

Title: Subtitle: Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae
Creators: A Rambukkana - Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, NY 10021, USA. rambuka@rockvax.rockefeller.edu
H Yamada
G Zanazzi
T Mathus
J L Salzer
P D Yurchenco
K P Campbell
V A Fischetti
Resource Type: Journal article
Publication Details: Science (American Association for the Advancement of Science), Vol.282(5396), pp.2076-2079
Publisher: United States
DOI: 10.1126/science.282.5396.2076
PMID: 9851927
ISSN: 0036-8075
eISSN: 1095-9203
Language: English
Date published: 12/11/1998
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
Record Identifier: 9984068276502771

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